160809-38-1Relevant articles and documents
PROGRANULIN MODULATORS AND METHODS OF USING THE SAME
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Paragraph 1013-1015, (2020/12/30)
Provided herein are compounds that modulate progranulin and methods of using the compounds in progranulin-associated disorders, such as Frontotemporal dementia (FTD).
Caspase inhibitor and pharmaceutical composition, application and treatment method thereof
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Paragraph 0062-0066, (2019/05/28)
The invention provides a compound serving as a caspase inhibitor and particularly relates to a novel compound with caspase inhibition activity or a pharmaceutically acceptable salt of the novel compound, a preparation method of the novel compound and a ph
Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL)
Korhonen, Jani,Kuusisto, Anne,Van Bruchem, John,Patel, Jayendra Z.,Laitinen, Tuomo,Navia-Paldanius, Dina,Laitinen, Jarmo T.,Savinainen, Juha R.,Parkkari, Teija,Nevalainen, Tapio J.
, p. 6694 - 6705 (2015/02/19)
The key hydrolytic enzymes of the endocannabinoid system, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), are potential targets for various therapeutic applications. In this paper, we present more extensively the results of our previous work on piperazine and piperidine carboxamides and carbamates as FAAH and MAGL inhibitors. The best compounds of these series function as potent and selective MAGL/FAAH inhibitors or as dual FAAH/MAGL inhibitors at nanomolar concentrations. This study revealed that MAGL inhibitors should comprise leaving-groups with a conjugate acid pKa of 8-10, while diverse leaving groups are tolerated for FAAH inhibitors.