1415-73-2

Basic information

• Product Name: Aloin
• Synonyms: barbaloin from aloe barbadensis*miller leaves;(R)-10-beta-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)anthracen-9(10H)-one;Aloin/Barbaloin;Barbaloin std.;BarbaloinStandard;9(10H)-Anthracenone, 10-.beta.-D-glucopyranosyl-1,8-dihydroxy-3-(hydroxymethyl)-, (10S)-;1,8-dihydroxy-10-(β-d-glucopyranosyl)-3-(hydroxymethyl)-9(10h)-anthracenone;ALOIN A(BARBALOIN)(P)
• CAS NO: 1415-73-2
• Molecular Formula: C₂₁H₂₂O₉
• Molecular Weight: 418.39
• EINECS: 232-398-9
• Product Categories: Natural Plant Extract;Plant extract;Herb extract;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
• Mol File: 1415-73-2.mol

Chemical Properties

• Melting Point: 148°C
• Boiling Point: 456.17°C (rough estimate)
• Flash Point: 268 ºC
• Appearance: yellow powder
• Density: 1.3028 (rough estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.6230 (estimate)
• Storage Temp.: 2-8°C
• Solubility: pyridine: 50 mg/mL, clear, dark red
• PKA: 7.12±0.40(Predicted)
• Stability: Stable, but light sensitive. Incompatible with bases, strong oxidizing agents. Combustible.
• BRN: 6077558
• CAS DataBase Reference: Aloin(CAS DataBase Reference)
• NIST Chemistry Reference: Aloin(1415-73-2)
• EPA Substance Registry System: Aloin(1415-73-2)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: LZ6520000
• F: 8
• Hazardous Substances Data: 1415-73-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Aloin is used as a stimulant-laxative for the treatment of constipation due to its natural occurrence in Aloe plant species and its historical use in this application.
Used in Anticancer Applications:
Aloin is being investigated as an antineoplastic agent, particularly for its potential to enhance melanogenesis and transglutaminase activity. This application is still under research, and its effectiveness in cancer treatment is yet to be fully established.
Used in Cosmetics Industry:
Given its potential to enhance melanogenesis, Aloin may also find use in the cosmetics industry for products aimed at improving skin pigmentation and promoting an even skin tone. However, further research and development are necessary to confirm its safety and efficacy in this application.

Safety Profile

Poison by subcutaneous andintravenous routes. Moderately toxic by ingestion. Whenheated to decomposition it emits acrid smoke and fumes.A carthartic and purgative.

Purification Methods

Aloin forms the monohydrate as lemon yellow crystals on crystallisation from H2O (450g/1.5L) which has a lower m ~70-80o than the anhydrous substance. [Cahn & Simonsen J Chem Soc 2573 1932, Hay & Haynes J Chem Soc 3141 1956.]

InChI:InChI=1/C21H22O9/c22-6-8-4-10-14(21-20(29)19(28)17(26)13(7-23)30-21)9-2-1-3-11(24)15(9)18(27)16(10)12(25)5-8/h1-5,13-14,17,19-26,28-29H,6-7H2/t13-,14?,17-,19+,20-,21+/m1/s1

Upstream product

• 6247-99-0 1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone 
• 572-09-8 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 

Downstream Products

• 481-72-1 1,8-dihydroxy-3-hydroxymethyl-9,10-anthracenedione 
• 10323-20-3 D-Arabinose 
• 6247-99-0 1,8-dihydroxy-3-(hydroxymethyl)-9(10H)-anthracenone 
• 481-74-3 Chrysophanol 
• 567-95-3 4,5-dihydroxy-2-hydroxymethyl-1,3,6,8-tetranitro-anthraquinone 

Related news

Ultrasonic-Assisted Extraction of Aloin (cas 1415-73-2) from Aloe Vera Gel☆09/29/2019

Ultrasound assisted extraction (UAE) intensifies the kinetic of the extraction process by acting upon the interfacial area, through the disintegration of particles. Compared with batch extraction, it improves the extraction process decreasing both extraction time and temperature while increasing...detailed

Full length articleRole of Aloin (cas 1415-73-2) in the modulation of certain immune parameters in skin mucus of an Indian major carp, Labeo rohita09/28/2019

Enhancement of immune system seems to be the most promising method of preventing fish diseases. Several herbal products have immunostimulant properties, and are environmental friendly, economical and can act against a broad spectrum of pathogens. Present study was designed with an aim to evaluat...detailed

Aloin (cas 1415-73-2) attenuates cognitive impairment and inflammation induced by d-galactose via down-regulating ERK, p38 and NF-κB signaling pathway10/01/2019

Oxidative stress is considered as major culprit for neurodegenerative diseases and triggers cognitive and memory impairments. The present study mainly aimed to study the protective effects and underlying mechanisms of aloin on d-galactose (d-gal) induced ageing mice. Our results demonstrated tha...detailed

Evaluation of efficacy of Aloin (cas 1415-73-2) in treating acute trauma in vitro and in vivo09/27/2019

Clinical multiple acute trauma has brought great suffering for patients. The use of traditional Chinese medicine provides a new approach to treating trauma. Aloe Vera gel has been used to treat skin diseases for a long time, but its efficacy is not stable. As the most important part of the organ...detailed

Aloin (cas 1415-73-2) reduces inflammatory gene iNOS via inhibition activity and p-STAT-1 and NF-κB09/26/2019

Aloin is the major anthraquinone glycoside obtained from the Aloe species and exhibits anti-inflammatory and anti-oxidative activities. Here, we aimed to determine the effects of aloin on heme oxygenase-1 (HO-1) induction and on the expressions of inducible nitric oxide synthase (iNOS) and cyclo...detailed

Original ArticleEffect of Aloin (cas 1415-73-2) on viral neuraminidase and hemagglutinin-specific T cell immunity in acute influenza09/25/2019

Background: Millions of people are infected by the influenza virus worldwide every year. Current selections of anti-influenza agents are limited and their effectiveness and drug resistance are still of concern.Purpose: Investigation on in vitro and in vivo effect of aloin from Aloe vera leaves a...detailed

Renal protective effects of Aloin (cas 1415-73-2) in a mouse model of sepsis09/24/2019

Aloin is the major anthraquinone glycoside obtained from the Aloe species and exhibits anti-inflammatory and anti-oxidative activities. However, the renal protective effects of aloin and underlying molecular mechanism remain unclear. This study was initiated to determine whether aloin could modu...detailed