14305-27-2

Basic information

• Product Name: 3-(4-chlorophenyl)-2,2-dimethylpropanoic acid methyl ester
• Synonyms: 3-(4-chlorophenyl)-2,2-dimethylpropanoic acid methyl ester
• CAS NO: 14305-27-2
• Molecular Weight: 226.703
• Mol File: 14305-27-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-(4-chlorophenyl)-2,2-dimethylpropanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-chlorophenyl)-2,2-dimethylpropanoic acid methyl ester(14305-27-2)
• EPA Substance Registry System: 3-(4-chlorophenyl)-2,2-dimethylpropanoic acid methyl ester(14305-27-2)

Safety Data

• Hazardous Substances Data: 14305-27-2(Hazardous Substances Data)

Upstream product

• 547-63-7 Methyl isobutyrate 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 31469-15-5 1-methoxy-2-methyl-1-trimethylsiloxy-1-propene 
• 1195-44-4 4-chlorobenzyl methyl ether 
• 622-95-7 4-chlorobenzyl bromide 
• 132381-68-1 S-4-chlorophenyl 2,2-dimethylpropanethioate 

Downstream Products

• 1308788-41-1 3-(4-chlorophenyl)-2,2-dimethyl-N-(pyridin-2-ylmethyl)propanamide 
• 1308788-88-6 3-(4-chlorobenzyl)-3-methyl-1-(pyridin-2-ylmethyl)pyrrolidine-2,5-dione 
• 57145-14-9 α-(4-Chloro-benzyl)-isobutyric acid 
• 63293-86-7 3-(4-chlorophenyl)-2,2-dimethylpropanoic acid chloride 
• 1613145-96-2 3-(4-chlorobenzyl)-3-methyl-1-(8-quinolinyl)-2-azetidinone 
• 1613146-03-4 4-(4-chlorophenyl)-3,3-dimethyl-1-(8-quinolinyl)-2-azetidinone 
• 1429896-54-7 3-(4-chlorophenyl)-2,2-dimethyl-N-(quinolin-8-yl)propanamide 
• 1429896-40-1 2-(4-chlorobenzyl)-3-(4-methoxyphenyl)-2-methyl-N-(quinolin-8-yl)propanamide 
• 80703-89-5 4-(4-chlorophenyl)-3,3-dimethyl-2-butanone 
• 80691-92-5 5-amino-1-(4-chlorophenyl)-2,2-dimethyl-3-hexanone 
• 80692-04-2 6-(4-chlorophenyl)-5,5-dimethyl-2,4-hexandione 
• 14248-27-2 3-(4-chlorophenyl)-2,2-dimethylpropan-1-ol 

Relevant articles and documents

Copper-catalyzed intramolecular C(sp3)-H and C(sp2)-H amidation by oxidative cyclization

The first copper-catalyzed intramolecular C(sp3)-H and C(sp 2)-H oxidative amidation has been developed. Using a Cu(OAc) 2 catalyst and an Ag2CO3 oxidant in dichloroethane solvent, C(sp3)-H

β-Arylation of carboxamides via iron-catalyzed C(sp3)-H bond activation

A 2,2-disubstituted propionamide bearing an 8-aminoquinolinyl group as the amide moiety can be arylated at the β-methyl position with an organozinc reagent in the presence of an organic oxidant, a catalytic amount of an iron salt, and a biphosphine ligand at 50 C. Various features of selectivity and reactivity suggest the formation of an organometallic intermediate via rate-determining C-H bond cleavage rather than a free-radical-type reaction pathway.

Indium-catalyzed coupling reaction between silyl enolates and alkyl chlorides or alkyl ethers

The coupling reactions of alkyl chlorides with silyl enolates catalyzed by InBr3, and the coupling reactions of alkyl ethers with silyl enolates catalyzed by the combined Lewis acid of InBr3/Me3SiBr are described. In both reaction systems, various types of silyl enolates were used to give corresponding α-alkylated esters, ketones, carboxylic acids, amides, thioesters, and aldehydes.