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Ethyl 3-oxo-3-[(3-ethoxy-3-oxopropyl)aMino]propanoate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

143300-67-8

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143300-67-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 143300-67-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,3,0 and 0 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 143300-67:
(8*1)+(7*4)+(6*3)+(5*3)+(4*0)+(3*0)+(2*6)+(1*7)=88
88 % 10 = 8
So 143300-67-8 is a valid CAS Registry Number.

143300-67-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Ethyl 3-[(3-ethoxy-3-oxo-propyl)amino]-3-oxo-propanoate

1.2 Other means of identification

Product number -
Other names N-(2-ethoxycarbonyl-ethyl)-malonamic acid ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:143300-67-8 SDS

143300-67-8Downstream Products

143300-67-8Relevant articles and documents

Furo-3-carboxamide derivatives and methods of use

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Page/Page column 55, (2017/10/24)

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, Z1, Z2, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

FURO-3-CARBOXAMIDE DERIVATIVES AND METHODS OF USE

-

Paragraph 0430, (2015/08/04)

Compounds of formula (I) and pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein R1, Z1, Z2, and n are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by Tropomysin receptor kinases (Trk). Methods for making the compounds are disclosed. Also disclosed are pharmaceutical compositions of compounds of formula (I), and methods for using such compounds and compositions.

Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors

Goto, Taiji,Shiina, Akiko,Yoshino, Toshiharu,Mizukami, Kiyoshi,Hirahara, Kazuki,Suzuki, Osamu,Sogawa, Yoshitaka,Takahashi, Tomoko,Mikkaichi, Tsuyoshi,Nakao, Naoki,Takahashi, Mizuki,Hasegawa, Masashi,Sasaki, Shigeki

, p. 7025 - 7037 (2013/11/06)

5-Carbamoyl-2-phenylpyrimidine derivative 2 has been identified as a phosphodiesterase 4 (PDE4) inhibitor with moderate PDE4B inhibitory activity (IC50 = 200 nM). Modification of the carboxylic acid moiety of 2 gave N-neopentylacetamide derivative 10f, which had high in vitro PDE4B inhibitory activity (IC50 = 8.3 nM) and in vivo efficacy against lipopolysaccharide (LPS)-induced pulmonary neutrophilia in mice (ID50 = 16 mg/kg, ip). Furthermore, based on the X-ray crystallography of 10f bound to the human PDE4B catalytic domain, we designed 7,8-dihydro-6H-pyrido[4,3-d] pyrimidin-5-one derivative 39 which has a fused bicyclic lactam scaffold. Compound 39 exhibited excellent inhibitory activity against LPS-induced tumor necrosis factor alpha (TNF-α) production in mouse splenocytes (IC 50 = 0.21 nM) and in vivo anti-inflammatory activity against LPS-induced pulmonary neutrophilia in mice (41% inhibition at a dose of 1.0 mg/kg, i.t.).

In vivo and in vitro SAR of tetracyclic MAPKAP-K2 (MK2) inhibitors. Part II

Revesz, Laszlo,Schlapbach, Achim,Aichholz, Reiner,Dawson, Janet,Feifel, Roland,Hawtin, Stuart,Littlewood-Evans, Amanda,Koch, Guido,Kroemer, Markus,Moebitz, Henrik,Scheufler, Clemens,Velcicky, Juraj,Huppertz, Christine

scheme or table, p. 4719 - 4723 (2010/09/16)

Spirocyclopropane- and spiroazetidine-substituted tetracycles 13D-E and 16A are described as orally active MK2 inhibitors. The spiroazetidine derivatives are potent MK2 inhibitors with IC50 50

INDOLONE MODULATORS OF 5-HT3 RECEPTOR

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Page/Page column 11, (2010/05/13)

The present invention relates to new indolone modulators of 5-HT3 receptor, pharmaceutical compositions thereof, and methods of use thereof.

ISOQUINOLINOPYRROLOPYRIDINONES ACTIVE AS KINASE INHIBITORS

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Page/Page column 22, (2008/12/07)

Heteroarylpyridinone derivatives represented by formula (I) wherein R1, R2, R3, R4, R5, and X are as defined in the specification, compositions thereof, and methods of use thereof. Particularly, there are described isoquinolinoyrrolopyridinones, pharmaceutical compositions comprising them and their use as therapeutic agents in the treatment of cancer and cell proliferation disorders.

N-substituted pyrrolopyridinones active as kinase inhibitors

-

Page/Page column 16-17, (2010/11/27)

Compounds represented by formula (I) wherein A, R1, R2, R3, R4, R5, and R6 are as defined in the specification, pharmaceutical compositions thereof, and methods of use thereof.

Dihydronaphthyridine potassium channel openers

-

, (2008/06/13)

Compounds of formula I are useful in treating diseases prevented by or ameliorated with potassium channel openers. Also disclosed are potassium channel opening compositions and a method of opening potassium channels in a mammal.

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