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Cas Database

1434-85-1

1434-85-1

Identification

  • Product Name:Estran-3-one, 17-hydroxy-, (5alpha,17beta)-

  • CAS Number: 1434-85-1

  • EINECS:

  • Molecular Weight:276.419

  • Molecular Formula: C18H28O2

  • HS Code:

  • Mol File:1434-85-1.mol

Synonyms:(5S,8R,9S,10S,13S,14S,17S)-17-hydroxy-13-methyl-2,4,5,6,7,8,9,10,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-one;1434-85-1;5-Dihydronandrolone;5-Dihydro-19-nortestosterone;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 3 Articles be found

HELIX 12 DIRECTED STEROIDAL PHARMACEUTICAL PRODUCTS

-

Page/Page column 128-129, (2010/02/12)

Compounds having the structure or their salts: are used to treat or reduce le likelihood of acquiring androgen-dependent diseases, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness. They can be formulated together with pharmaceutically acceptable diluent or carrier or otherwise made into any pharmaceutical dosage form. Some of these compounds having tissue-specific antiandrogenic activity and tissue-specific androgenic activity can be used to treat or reduce the risk of developing diseases related to loss of androgenic stimulation. Combinations with other active pharmaceutical agents are also disclosed.

Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABA(A) receptors

Han, Mingcheng,Zorumski, Charles F.,Covey, Douglas F.

, p. 4218 - 4232 (2007/10/03)

A series of analogues of the neuroactive steroids 3α-hydroxy-5α- pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one were studied to elucidate the mode of binding of 5α- and 5β-reduced steroids to steroid binding sites on GABA(A) receptors. Analogues which were either 3α-hydroxy-20-ketosteroids or 3α-hydroxysteroid-17β-carbonitriles and which contained various methyl group substitution patterns at C-5 and C-10 were prepared. Evaluations utilized whole-cell patch clamp electrophysiological methods carried out on cultured rat hippocampal neurons, and the results obtained with the rigid 17β-carbonitrile analogs were analyzed using molecular modeling methods. The molecular modeling results provide a rationale for the observation that the configuration of the hydroxyl group at C-3 is a greater determinant of anesthetic potency than the configuration of the A,B ring fusion at C-5. The electrophysiological results identify steric restrictions for the space that can be occupied in 5α- and 5β-reduced steriod modulators of GABA(A) recepters in the regions of space proximate to the steroid C-5, C-10, and possibly C-4 positions. This information is useful for the development of nonsteroidal analogues that can modulate GABA(A) receptors via interactions at steroid binding sites.

Formation of 5α steroids by biotranformation involving the 5 α-reductase activity of Penicillium decumbens

Holland, Herbert L.,Dore, Sophia,Xu, Weili,Brown, Frances M.

, p. 642 - 647 (2007/10/02)

The biotransformation of a series of Δ4-3-ketosteroids by the Penicillium decumbens ATCC 10436 has been investigated. Conversion to the 5α-dihydrosteroid was observed substrates of the androsterone and pregne series: the reaction is tolerant of non-polar substituents (Cl and CH3) at C-4 of the substrate, but does not occur in the presence of a 4-hydroxyl group, or with additional unsaturation at the Δ1 or Δ6 positions. A-nor, B-nor, 3-deoxy-, and 3,5-cycloandrostanes are not reduced, but 6-methylenestestosterone is converted to a 6-methylene-5α-dihydro derivative. Several biotransformations are reported which involve oxidoreductase activity at C-3 and/or C-17, either concomitant or independent of Δ4 reduction: the substrate specificity of the oxidoreductase processes has been examined and defined by the use of 3α-hydroxy, 3β-hydroxy, 3-keto, 17β-keto substituted steroids. In this way, the existence in P. decumbens of 3β-hydroxy-3-keto and 17β-hydroxy-17-keto oxidoreductases has been demonstrated.

Process route upstream and downstream products

Process route

19-nortestosterone
434-22-0

19-nortestosterone

estra-4-ene-3,17-dione
734-32-7

estra-4-ene-3,17-dione

17β-hydroxy-5α-estran-3-one
1434-85-1

17β-hydroxy-5α-estran-3-one

Conditions
Conditions Yield
With potato dextrose broth medium; In ethanol; at 24 - 26 ℃; for 96h; Penicillium decumbens ATCC 10436;
10%
45%
C<sub>18</sub>H<sub>27</sub>IO<sub>2</sub>

C18H27IO2

iodomethylbenzoate
13943-33-4

iodomethylbenzoate

5a-dihydro-18-(benzoyloxymethylene)-19-nortestosterone

5a-dihydro-18-(benzoyloxymethylene)-19-nortestosterone

Conditions
Conditions Yield
With manganese; copper dichloride; In tetrahydrofuran; water; at 20 ℃; for 24h;
27%
47%
19-nortestosterone
434-22-0

19-nortestosterone

17β-hydroxy-5α-estran-3-one
1434-85-1

17β-hydroxy-5α-estran-3-one

5α‐estrane‐3β,17β‐diol
1816-75-7

5α‐estrane‐3β,17β‐diol

5β‐estrane‐3α,17β‐diol
10002-97-8

5β‐estrane‐3α,17β‐diol

17β-hydroxy-19-nor-5β-androstan-3-one
19468-31-6

17β-hydroxy-19-nor-5β-androstan-3-one

Conditions
Conditions Yield
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Yields of byproduct given; Ambient temperature;
16%
7%
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Title compound not separated from byproducts; Ambient temperature;
7%
16%
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Ambient temperature;
7%
16%
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Yield given; Ambient temperature;
7%
16%
19-nortestosterone
434-22-0

19-nortestosterone

17β-hydroxy-5α-estran-3-one
1434-85-1

17β-hydroxy-5α-estran-3-one

5β‐estrane‐3α,17β‐diol
10002-97-8

5β‐estrane‐3α,17β‐diol

17β-hydroxy-19-nor-5β-androstan-3-one
19468-31-6

17β-hydroxy-19-nor-5β-androstan-3-one

5β-estrane-3,17-dione
5696-51-5

5β-estrane-3,17-dione

Conditions
Conditions Yield
With chromium(VI) oxide; potassium hydroxide; sulfuric acid; hydrogen; palladium on activated charcoal; Yield given. Multistep reaction. Title compound not separated from byproducts; 1.) 2-propanol, from 40 to 45 psi, RT, 2.) acetone, RT, 30 min;
19-nortestosterone
434-22-0

19-nortestosterone

estra-4-ene-3,17-dione
734-32-7

estra-4-ene-3,17-dione

17β-hydroxy-5α-estran-3-one
1434-85-1

17β-hydroxy-5α-estran-3-one

Conditions
Conditions Yield
With potato dextrose broth medium; In ethanol; at 24 - 26 ℃; for 96h; Penicillium decumbens ATCC 10436;
10%
45%
C<sub>18</sub>H<sub>27</sub>IO<sub>2</sub>

C18H27IO2

iodomethylbenzoate
13943-33-4

iodomethylbenzoate

5a-dihydro-18-(benzoyloxymethylene)-19-nortestosterone

5a-dihydro-18-(benzoyloxymethylene)-19-nortestosterone

Conditions
Conditions Yield
With manganese; copper dichloride; In tetrahydrofuran; water; at 20 ℃; for 24h;
27%
47%
19-nortestosterone
434-22-0

19-nortestosterone

17β-hydroxy-5α-estran-3-one
1434-85-1

17β-hydroxy-5α-estran-3-one

5α‐estrane‐3β,17β‐diol
1816-75-7

5α‐estrane‐3β,17β‐diol

5β‐estrane‐3α,17β‐diol
10002-97-8

5β‐estrane‐3α,17β‐diol

17β-hydroxy-19-nor-5β-androstan-3-one
19468-31-6

17β-hydroxy-19-nor-5β-androstan-3-one

Conditions
Conditions Yield
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Yields of byproduct given; Ambient temperature;
16%
7%
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Title compound not separated from byproducts; Ambient temperature;
7%
16%
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Ambient temperature;
7%
16%
With potassium hydroxide; hydrogen; palladium on activated charcoal; In isopropyl alcohol; under 2068.6 - 2327.2 Torr; Yield given; Ambient temperature;
7%
16%
19-nortestosterone
434-22-0

19-nortestosterone

17β-hydroxy-5α-estran-3-one
1434-85-1

17β-hydroxy-5α-estran-3-one

5β‐estrane‐3α,17β‐diol
10002-97-8

5β‐estrane‐3α,17β‐diol

17β-hydroxy-19-nor-5β-androstan-3-one
19468-31-6

17β-hydroxy-19-nor-5β-androstan-3-one

5β-estrane-3,17-dione
5696-51-5

5β-estrane-3,17-dione

Conditions
Conditions Yield
With chromium(VI) oxide; potassium hydroxide; sulfuric acid; hydrogen; palladium on activated charcoal; Yield given. Multistep reaction. Title compound not separated from byproducts; 1.) 2-propanol, from 40 to 45 psi, RT, 2.) acetone, RT, 30 min;

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  • NovaChemistry
  • Business Type:Trading Company
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  • Emails:info@novachemistry.com
  • Main Products:1
  • Country:United Kingdom
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