143767-54-8 Usage
General Description
2-ACETYL-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID, also known as TIQ-AMP or 1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid, is a chemical compound that belongs to the class of isoquinoline alkaloids. It is a derivative of tetrahydroisoquinoline and is commonly used in the synthesis of various pharmaceuticals and organic compounds. This chemical has been studied for its potential therapeutic applications, particularly in the field of neuroscience, due to its apparent ability to modulate neurotransmitter systems in the brain. It is also used as a building block for the synthesis of various biologically active molecules and pharmaceutical intermediates. Further research is ongoing to explore the potential pharmacological properties and applications of 2-ACETYL-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINECARBOXYLIC ACID.
Check Digit Verification of cas no
The CAS Registry Mumber 143767-54-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,7,6 and 7 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 143767-54:
(8*1)+(7*4)+(6*3)+(5*7)+(4*6)+(3*7)+(2*5)+(1*4)=148
148 % 10 = 8
So 143767-54-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H13NO3/c1-8(14)13-7-10-5-3-2-4-9(10)6-11(13)12(15)16/h2-5,11H,6-7H2,1H3,(H,15,16)
143767-54-8Relevant articles and documents
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Archer
, p. 430 (1951)
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3-Hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4- tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity
Grunewald, Gary L.,Romero, F. Anthony,Criscione, Kevin R.
, p. 134 - 140 (2007/10/03)
Six 3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4- tetrahydroisoquinolines (16-21) were synthesized and evaluated for their phenylethanolamine N-methyltransferase (PNMT) inhibitory potency and affinity for the α2-adrenoceptor. The add
Efficient synthesis of racemic and enantiomerically pure 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and esters
Kammermeier,Lerch,Sommer
, p. 1157 - 1160 (2007/10/02)
Racemic and optically pure 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids and esters were prepared, via base-catalyzed cyclization of 1,2-bis(halomethyl)benzenes 1a or b with diethyl 2-(acetylamino)malonate (2), subsequent decarboxylation and amide cleavage. The enantiomer resolution was achieved either by esterification with (-)-menthol followed by column chromatographic separation of the diastereomeric mixture or by diasteromeric salt separation of the benzylic ester with mandelic acid and base-catalyzed saponification of both esters.
