143824-77-5

Basic information

• Product Name: FMOC-ARG(BOC)2-OH
• Synonyms: N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N',N''-BIS-TERT-BUTYLOXYCARBONYL-L-ARGININE;N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-N-OMEGA1,N-OMEGA2-DI-T-BUTOXYCARBONYL-L-ARGININE;N-ALPHA-FMOC-N-OMEGA,N-OMEGA'-BIS-T-BUTOXYCARBONYL-L-ARGININE;N-ALPHA-FMOC-NG,NG-DIBOC-L-ARGININE;FMOC-ARG(BOC)2-OH;FMOC-ARGININE(BOC)2-OH;FMOC-L-ARG(BOC)2-OH;FMOC-N-OMEGA,N-OMEGA'-BIS-BOC-L-ARGININE
• CAS NO: 143824-77-5
• Molecular Formula: C₃₁H₄₀N₄O₈
• Molecular Weight: 596.67
• Product Categories: Amino Acids;amino acid
• Mol File: 143824-77-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /Solid
• Density: 1.255g/cm3
• Refractive Index: 1.581
• Storage Temp.: -15°C
• PKA: 3.80±0.21(Predicted)
• CAS DataBase Reference: FMOC-ARG(BOC)2-OH(CAS DataBase Reference)
• NIST Chemistry Reference: FMOC-ARG(BOC)2-OH(143824-77-5)
• EPA Substance Registry System: FMOC-ARG(BOC)2-OH(143824-77-5)

Safety Data

• Hazardous Substances Data: 143824-77-5(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

Fmoc-Arg(Boc)2-OH is an intermediate used in membrane enhanced peptide synthesis.

InChI:InChI=1/C31H40N4O8/c1-30(2,3)42-28(39)34-26(35-29(40)43-31(4,5)6)32-17-11-16-24(25(36)37)33-27(38)41-18-23-21-14-9-7-12-19(21)20-13-8-10-15-22(20)23/h7-10,12-15,23-24H,11,16-18H2,1-6H3,(H,33,38)(H,36,37)(H2,32,34,35,39,40)/t24-/m0/s1

Upstream product

• 83585-01-7 Z-Arg^ω,ω'(Boc)2-OH 
• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 
• 152120-54-2 N,N'-bis( tert-butoxycarbonyl)-1H-pyrazole-1-carboxamidine 
• 207857-15-6 1,3-di(tert-butyloxycarbonyl)-2-(trifluoromethylsulfonyl)guanidine 
• 201046-57-3 N^α-(9-fluorenylmethoxy)carbonyl-L-ornithine hydrochloride 
• 332882-82-3 1,3-bis(t-butoxycarbonyl)guanidine 
• 70-26-8 L-ornithine 
• 102774-86-7 9-fluorenylmethyl N-succinimidyl carbonate 
• 145315-38-4 H-L-Arg(Boc)₂-OH 
• 158599-00-9 (S)-5-Amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanoic acid 
• 107819-90-9 1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 
• 2640-58-6 Nα-benzyloxycarbonyl-L-ornithine 
• 145315-38-4 H-Arg^ω,ω'(Boc)2-OH 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1207730-31-1 C₂₄H₃₇N₇O₈ 
• 1207730-30-0 C₂₆H₄₄N₈O₆ 
• 69558-55-0 thymopentin 
• 75957-56-1 H-Lys-Asp-Val-Tyr-OH 

Relevant articles and documents

Modular Solid-Phase Synthesis of Antiprotozoal Barnesin Derivatives

Here, we applied and optimized a solid support (SP)-based Horner-Wadsworth-Emmons reagent to prepare SP-bound vinylogous amino acids. Subsequent SP-based peptide synthesis, global deprotection, and chemical modifications yielded 14 lipodipeptides carrying

Miraziridine A: Natures blueprint towards protease class-spanning inhibitors

The natural product miraziridine A isolated from the marine sponge Theonella aff. mirabilis unifies within one molecule three structurally privileged elements: (i) (2R,3R)-aziridine-2,3-dicarboxylic acid, (ii) (3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid (statine), and (iii) (E)-(S)-4-amino-7-guanidino-hept-2-enoic acid (vinylogous arginine). The alignment of them realized in the tetrapetide allows for a simultaneous inhibition of the proteolytic activity of trypsin-like serine proteases, papain-like cysteine proteases, and pepsin-like aspartyl proteases. Therefore, this unique compound represents a blueprint for the design of protease class-spanning inhibitors.

A facile preparation of Fmoc-Argω,ω′(Boc)2 -OH and Z-Argω,ω′ (Boc)2 -OH, new arginine derivatives for peptide synthesis

The new arginine derivatives Fmoc-Argω,ω′(Boc)2 -OH and Z-Argω,ω′ (Boc)2 -OH have been easily prepared in hiqh yield starting from Z-Orn-OH and N,N′-bis (tert-butoxycarbonyl) -S-methylisothiourea.