144060-96-8

Basic information

• Product Name: Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate
• Synonyms: Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate;Ethy1,2-(3-bromo-4-isobutoxyphenyl)-4-methyl-5-thiazolecarbokylate;2-[3-broMo-4-(2-Methylpropoxy)phenyl]-5-carboxylato-1-ethyl-4-Methyl-1H-1$l^{4},3-thiazol-1-yl;ethyl 2-(3-broMo-4-isobutoxyphenyl)-4-Methylthiazole-5-carboxylate;2-(3-bromo-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester
• CAS NO: 144060-96-8
• Molecular Formula: C₁₇H₂₀BrNO₃S
• Molecular Weight: 398.319
• EINECS: 1533716-785-6
• Mol File: 144060-96-8.mol

Chemical Properties

• Boiling Point: 476.5 °C at 760 mmHg
• Flash Point: 242 °C
• Appearance: /
• Density: 1.335 g/cm³
• Vapor Pressure: 3.02E-09mmHg at 25°C
• Refractive Index: 1.562
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate(144060-96-8)
• EPA Substance Registry System: Ethyl 2-(3-bromo-4-isobutoxyphenyl)- 4-methyl-5-thiazolecarboxylate(144060-96-8)

Safety Data

• Hazardous Substances Data: 144060-96-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-(3-bromo-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is used as a building block for the synthesis of pharmaceuticals due to its versatile reactivity and potential biological activities. Its presence in the structure suggests possible antimicrobial and antifungal properties, making it a valuable compound in drug discovery and development.
Used in Agrochemical Industry:
In the agrochemical industry, Ethyl 2-(3-bromo-4-isobutoxyphenyl)-4-methyl-5-thiazolecarboxylate is utilized as a key intermediate in the synthesis of agrochemicals, leveraging its reactivity and potential for biological activity to create effective compounds for agricultural applications.
Used in Drug Discovery and Development:
Ethyl 2-(3-bromo-4-isobutoxyphenyl)4-methyl-5-thiazolecarboxylate is employed in drug discovery and development processes for its potential to contribute to the creation of new therapeutic agents. The ethyl ester functional group at the 5-position of the thiazole ring enhances the compound's pharmacokinetic properties and bioavailability, which is crucial for the effectiveness of medicinal formulations.

InChI:InChI=1/C17H20BrNO3S/c1-5-21-17(20)15-11(4)19-16(23-15)12-6-7-14(13(18)8-12)22-9-10(2)3/h6-8,10H,5,9H2,1-4H3

Upstream product

• 208665-96-7 3-bromo-4-isobutoxyphenylthiocarboxamide 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 144060-79-7 2-(3-bromo-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester 
• 78-77-3 Isobutyl bromide 
• 2315-86-8 3-bromo-4-hydroxybenzonitrile 
• 2973-78-6 3-bromo-4-hydroxybenzylaldehyde 
• 25984-64-9 3-bromo-4-hydroxy-thiobenzamide 

Downstream Products

• 144060-85-5 ethyl 2-(4-isobutyloxy-3-trifluoromethylphenyl)-4-methyl-5-thiazolecarboxylate 
• 160844-75-7 2-(3-cyano-4-isobutyloxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester 
• 1364398-15-1 ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate hydrochloride 

Relevant articles and documents

PROCESS TO PREPARE ETHYL 4-METHYL-2-(4-(2-METHYLPROPYLOXY)-3-CYANOPHENYL)-5-THIAZOLECARBOXYLATE

Disclosed is a process for the preparation of Ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate (I) the key intermediate for the preparation of [2-[3-cyano-4-(2-Methyl-propoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (Febuxostat, I(A)) is approved under the trademark Uloric? by the US Food and Drug Administration for the treatment of hyperuricemia and gouty arthritis.

IMPROVED PROCESS TO PREPARE ETHYL 4-METHYL-2-(4-(2-METHYLPROPYLOXY)-3-CYANOPHENYL)-5-THIAZOLECARBOXYLATE

Disclosed is a process for the preparation of Ethyl 4-methyl-2-(4-(2-methylpropyloxy)-3-cyanophenyl)-5-thiazolecarboxylate (I) the key intermediate for the preparation of [2-[3-cyano-4-(2-Methyl-propoxy)phenyl]-4-methyl-5-thiazole carboxylic acid (Febuxostat, I(A)) is approved under the trademark Uloric ? by the US Food and Drug Administration for the treatment of hyperuricemia and gouty arthritis.

A PROCESS FOR THE PREPARATION OF FEBUXOSTAT

The present invention relates to a process for the preparation of Febuxostat, useful in the pharmaceutical field for the treatment of the hyperuricemia.