147083-36-1

Basic information

• Product Name: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine
• Synonyms: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine;CL136
• CAS NO: 147083-36-1
• Molecular Formula: C18H21N3
• Molecular Weight: 279.37944
• EINECS: -0
• Mol File: 147083-36-1.mol

Chemical Properties

• Boiling Point: 501.1±60.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• PKA: 8.71±0.20(Predicted)
• CAS DataBase Reference: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine(CAS DataBase Reference)
• NIST Chemistry Reference: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine(147083-36-1)
• EPA Substance Registry System: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine(147083-36-1)

Safety Data

• Hazardous Substances Data: 147083-36-1(Hazardous Substances Data)

Usage

Uses

Due to the limited information available on the specific uses of 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]imidazo[1,2-a]azepine, it is not possible to provide a comprehensive list of its applications. However, given its classification as an azepine compound, it can be inferred that it may have potential applications in various industries, such as pharmaceuticals, materials science, or chemical research. Further research and investigation would be required to determine its specific uses and benefits in these fields.

Upstream product

• 24252-37-7 ethyl 1-methylisonipecotate 
• 60-12-8 2-phenylethanol 
• 118133-15-6 1-ethoxycarbonylpiperidine-4-carboxylic acid 
• 498-94-2 isonipecotic acid 
• 50-00-0 formaldehyd 
• 142654-73-7 11-piperidin-4-ylidene-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine 
• 49823-14-5 1-(2-phenylethyl)-1H-imidazole 

Relevant articles and documents

METHODS FOR THE PREPARATION OF ALCAFTADINE

The invention relates to new and improved processes for the preparation of Alcaftadine and pharmaceutically acceptable salts thereof as well as an intermediate for the preparation of Alcaftadine. The new process saves a number of steps compared to the known process and results in a higher yield.

A PROCESS FOR THE PREPARATION OF ALCAFTADINE

An improved process for preparation of Alcaftadine, its crystalline form or its pharmaceutically acceptable salts is disclosed alongwith a process for purification of Alcaftadine or its pharmaceutically acceptable salts.

Imidazo[2,1-b]benzazepine derivatives, compositions and method of use

The present invention is concerned with novel imidazo[2, 1-b][3]benzazepines of formula STR1 the pharmaceutically acceptable addition salts and stereochemically isomeric forms thereof, wherein each of the dotted lines independently represents an optional bond; R1 represents hydrogen, halo, C1-4 alkyl or C1-4 alkyloxy; R2 represents hydrogen, halo, C1-4 alkyl or C1-4 alkyloxy; R3 represents hydrogen, C1-4 alkyl, ethenyl substituted with hydroxycarbonyl or C1-4 alkyloxycarbonyl, C1-4 alkyl substituted with hydroxycarbonyl or C1-4 alkyloxycarbonyl, hydroxyC1-4 alkyl, formyl or hydroxycarbonyl; R4 represents hydrogen, C1-4 alkyl, hydroxyC1-4 alkyl, phenyl or halo; R5 represents hydrogen, C1-4 alkyl or halo; L represents hydrogen; C1-6 alkyl; C1-6 alkyl substituted with one substituent selected from the group consisting of hydroxy, halo, C1-4 alkyloxy, hydroxycarbonyl, C1-4 alkyloxycarbonyl, C1-4 alkyloxycarbonyl-C1-4 alkyloxy, hydroxycarbonylC1-4 alkyloxy, C1-4 alkyloxycarbonylamino, C1-4 alkylaminocarbonyl, C1-4 alkylaminocarbonylamino, C1-4 alkylaminothiocarbonylamino, aryl, aryloxy and arylcarbonyl; C1-6 alkyl substituted with both hydroxy and aryloxy; C3-6 alkenyl; C3-6 alkenyl substituted with aryl; or, L represents a radical of formula --Alk--Y--Het1 (a-1),--Alk--NH--CO--Het2 (a-2)or --Alk--Het3 (a-3); provided that 6,11-dihydro-11-(4-piperidinylidene)-5H-imidazo[2,1-b][3]benzazepine is ecxluded, which are useful antiallergic compounds. Compositions comprising said compounds, methods of using and processes for preparing the same.