11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine

Base Information

• Chemical Name: 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine
• CAS No.: 147083-36-1
• Molecular Formula: C₁₈H₂₁N₃
• Molecular Weight: 279.385
• Mol file: 147083-36-1.mol

Synonyms:11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine

Chemical Property of 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine

Chemical Property:

• Boiling Point: 501.1±60.0 °C(Predicted)
• PKA: 8.71±0.20(Predicted)
• PSA: 21.06000
• Density: 1.19±0.1 g/cm3(Predicted)
• LogP: 2.90460

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine

There total 13 articles about 11-(1-Methylpiperidin-4-ylidene)-6,11-dihydro-5H-benzo[d]iMidazo[1,2-a]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1-methylpiperidine-4-yl)[1-(2-phenylethyl)-1H-imidazol-2-yl]methanone hydrobromide → 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine (147083-36-1)

Guidance literature:

(1-methylpiperidine-4-yl)[1-(2-phenylethyl)-1H-imidazol-2-yl]methanone hydrobromide; With sodium hydroxide; In water; at 25 - 30 ℃;

With trifluorormethanesulfonic acid; at 25 - 145 ℃; for 1h;

Reference yield:

[1-(2-phenylethyl)-1H-imidazol-2-yl](1-methyl-4-piperidinyl)-methanone → 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine (147083-36-1)

Guidance literature:

With trifluorormethanesulfonic acid; at 105 ℃; for 6h;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 11-piperidin-4-ylidene-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine (142654-73-7) → 11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine (147083-36-1)

Guidance literature:

With formic acid; at 75 - 80 ℃; for 1h; Time; Temperature;

upstream raw materials:

1-(2-phenylethyl)-1H-imidazole

formaldehyd

11-piperidin-4-ylidene-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine

isonipecotic acid