1492-11-1

Basic information

• Product Name: AC-LEU-OME
• Synonyms: AC-LEU-OME;AC-LEUCINE-OME;ACETYL-L-LEUCINE METHYL ESTER;N-ALPHA-ACETYL-L-LEUCINE METHYL ESTER;N-Acetyl-L-leucine methyl ester;Ac-L-Leu-OMe;(2S)-2-(Acetylamino)-4-methylpentanoic acid methyl ester;N-Acetylleucine methyl ester
• CAS NO: 1492-11-1
• Molecular Formula: C₉H₁₇NO₃
• Molecular Weight: 187.24
• Product Categories: Amino Acids
• Mol File: 1492-11-1.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 291.7 °C at 760 mmHg
• Flash Point: 130.2 °C
• Appearance: /
• Density: 0.999 g/cm³
• Storage Temp.: Store at RT.
• CAS DataBase Reference: AC-LEU-OME(CAS DataBase Reference)
• NIST Chemistry Reference: AC-LEU-OME(1492-11-1)
• EPA Substance Registry System: AC-LEU-OME(1492-11-1)

Safety Data

• Hazardous Substances Data: 1492-11-1(Hazardous Substances Data)

Usage

Description

AC-LEU-OME is a synthetic chemical compound with the amino acid sequence acetyl-leucine-ornithine-methyl ester, often utilized in pharmaceutical and biotechnological research and development. It is a modified peptide that has garnered attention for its potential as a drug delivery system, as well as its antimicrobial, antifungal, and antioxidant properties. AC-LEU-OME's versatility and therapeutic benefits have made it a subject of interest within the scientific community, with ongoing research aimed at exploring its various applications.

Uses

Used in Pharmaceutical Research and Development:
AC-LEU-OME is used as a drug delivery system for enhancing the efficacy and targeting of therapeutic agents. Its unique properties allow for the controlled release and improved bioavailability of drugs, making it a promising candidate for the development of novel pharmaceutical formulations.
Used in Antimicrobial Applications:
AC-LEU-OME is used as an antimicrobial agent for its ability to inhibit the growth of various microorganisms. Its broad-spectrum activity makes it a valuable tool in combating bacterial infections and reducing the risk of antibiotic resistance.
Used in Antifungal Applications:
AC-LEU-OME is used as an antifungal agent for its potential to treat fungal infections. Its ability to target and disrupt fungal cell structures contributes to its effectiveness in controlling and preventing fungal growth.
Used in Antioxidant Applications:
AC-LEU-OME is used as an antioxidant for its potential to neutralize harmful free radicals and protect cells from oxidative damage. This property makes it a candidate for use in various medical applications, including the prevention and treatment of diseases associated with oxidative stress.
Used in Biotechnology:
AC-LEU-OME is used in biotechnological applications for its potential to enhance the production of bioactive compounds and improve the efficiency of biological processes. Its unique properties may contribute to the development of innovative biotechnological solutions in various industries.

Upstream product

• 57289-25-5 methyl N-acetyl-leucinate 
• 186581-53-3 diazomethane 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 108-24-7 acetic anhydride 
• 67-56-1 methanol 
• 1188-21-2 N-Ac-Leu 
• 6600-40-4 L-Norvaline 
• 61-90-5 L-leucine 
• 139551-80-7 N^α-Fmoc-Leu-OMe 
• 64-19-7 acetic acid 
• 203873-66-9 (S)-methyl 4-methyl-2-(4-nitrophenylsulfonamido)pentanoate 
• 66299-18-1 Methyl (Z)-2-(iodoacetamido)-4-methylpent-2-enoate 
• 66299-17-0 Methyl (E)-2-(iodoacetamido)-4-methylpent-2-enoate 
• 63861-79-0 Methyl (Z)-2-(chloroacetamido)-4-methylpent-2-enoate 

Downstream Products

• 32483-15-1 Ac-Leu-NHMe 
• 464-72-2 tetraphenylethane-1,2-diol 
• 2666-93-5 (S)-Leu-OMe 
• 61-90-5 L-leucine 
• 28529-34-2 N-acetyl-L-leucine amide 

Relevant articles and documents

Engineering a polymeric chiral catalyst by using hydrogen bonding and coordination interactions

(Chemical Equation Presented) Noncovalent interactions are used to generate a polymeric supramolecular chiral catalyst (see picture). This heterogeneous catalyst, which is based on Feringa's MonoPhos/RhI system, is formed by orthogonal self-ass

The First Application of a Planar-Chiral Phosphorus Heterocycle in Asymmetric Catalysis: Enantioselective Hydrogenation of Dehydroamino Acids

-

Oxidative functionalization of aliphatic and aromatic amino acid derivatives with H2O2 catalyzed by a nonheme imine based iron complex

The oxidation of a series of N-acetyl amino acid methyl esters with H2O2 catalyzed by a very simple iminopyridine iron(ii) complex 1 easily obtainable in situ by self-assembly of 2-picolylaldehyde, 2-picolylamine, and Fe(OTf)2 was investigated. Oxidation of protected aliphatic amino acids occurs at the α-C-H bond exclusively (N-AcAlaOMe) or in competition with the side-chain functionalization (N-AcValOMe and N-AcLeuOMe). N-AcProOMe is smoothly and cleanly oxidized with high regioselectivity affording exclusively C-5 oxidation products. Remarkably, complex 1 is also able to catalyze the oxidation of the aromatic N-AcPheOMe. A marked preference for the aromatic ring hydroxylation over Cα-H and benzylic C-H oxidation was observed, leading to the clean formation of tyrosine and its phenolic isomers.

IMMUNOSTIMULATING AGENT

The present invention aims to provide an immunostimulating agent superior in an immunostimulatory effect, particularly a compound useful as a vaccine adjuvant, a pharmaceutical composition containing the compound, a vaccine containing the compound and an