149338-26-1Relevant articles and documents
Synthesis and pharmacological properties of 2-nitro-3-substituted-amino benzo[b]thiophenes and their 5-chloro derivatives
Guerrera,Salerno,Sarva,Siracusa,Lamartina,Caruso,Cutuli
, p. 1149 - 1160 (2007/10/02)
This paper reports the synthesis and the pharmacological evaluation of some 2-nitro-3-N-phenylamino-benzo[b]-thiophenes and 5-chloro derivatives of the most active of these compounds; in addition, some 5-chloro derivatives of 2-nitro-3-alkylen- or phenylen-diamino-benzo[b]thiophenes previously synthesized were prepared. These compounds were screened for analgesic, antiexudative and antiinflammatory activities related to phenylbutazone. Nitration of 5-chloro-3-bromobenzo[b]thiophene was also studied.