32969-26-9

Basic information

• Product Name: 3-BROMO-5-CHLOROBENZO[B]THIOPHENE
• Synonyms: 3-BROMO-5-CHLOROBENZO[B]THIOPHENE
• CAS NO: 32969-26-9
• Molecular Formula: C8H4BrClS
• Molecular Weight: 247.53936
• Mol File: 32969-26-9.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 320.76°C at 760 mmHg
• Flash Point: 147.79°C
• Appearance: /
• Density: 1.754g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.708
• CAS DataBase Reference: 3-BROMO-5-CHLOROBENZO[B]THIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-CHLOROBENZO[B]THIOPHENE(32969-26-9)
• EPA Substance Registry System: 3-BROMO-5-CHLOROBENZO[B]THIOPHENE(32969-26-9)

Safety Data

• Hazardous Substances Data: 32969-26-9(Hazardous Substances Data)

Usage

General Description

3-Bromo-5-chlorobenzo[b]thiophene is a chemical compound with the molecular formula C8H4BrClS. It is a heterocyclic aromatic compound containing a thiophene ring with a bromine atom at the 3-position and a chlorine atom at the 5-position. 3-BROMO-5-CHLOROBENZO[B]THIOPHENE is commonly used in organic synthesis and pharmaceutical research, with potential applications in the development of new drugs and materials. Its unique structure and reactivity make it a valuable building block for the synthesis of complex molecules and biologically active compounds. Additionally, 3-Bromo-5-chlorobenzo[b]thiophene is also used as a precursor in the production of various specialty chemicals and agrochemicals. Its availability and versatility make it an important intermediate in the chemical industry, with a wide range of potential applications.

InChI:InChI=1/C8H4BrClS/c9-7-4-11-8-2-1-5(10)3-6(7)8/h1-4H

Upstream product

• 50548-46-4 (4-chlorophenyl)(2,2-diethoxyethyl)sulfane 
• 106-54-7 p-Chlorothiophenol 
• 20532-33-6 5-chlorobenzothiophene 

Downstream Products

• 149338-19-2 1-[3-(5-Chloro-2-nitro-benzo[b]thiophen-3-ylamino)-propyl]-pyrrolidin-2-one 
• 149338-24-9 N-(5-Chloro-2-nitro-benzo[b]thiophen-3-yl)-N',N'-diethyl-benzene-1,4-diamine 
• 149338-22-7 (5-Chloro-2-nitro-benzo[b]thiophen-3-yl)-(3-morpholin-4-yl-propyl)-amine 
• 149338-20-5 (5-Chloro-2-nitro-benzo[b]thiophen-3-yl)-[3-(2-methyl-piperidin-1-yl)-propyl]-amine 
• 149338-23-8 N-(5-Chloro-2-nitro-benzo[b]thiophen-3-yl)-N',N'-dimethyl-benzene-1,4-diamine 
• 149338-21-6 (5-Chloro-2-nitro-benzo[b]thiophen-3-yl)-(2-morpholin-4-yl-ethyl)-amine 
• 149338-25-0 (5-Chloro-2-nitro-benzo[b]thiophen-3-yl)-(4-chloro-phenyl)-amine 
• 149338-26-1 (5-Chloro-2-nitro-benzo[b]thiophen-3-yl)-(4-fluoro-phenyl)-amine 
• 149338-18-1 (5-Chloro-2-nitro-benzo[b]thiophen-3-yl)-(2-pyrrolidin-1-yl-ethyl)-amine 

Relevant articles and documents

Catalytic Asymmetric Dearomative 1,3-Dipolar Cycloaddition of 2-Nitrobenzothiophenes and Isatin-Derived Azomethine Ylides

An enantioselective dearomative 1,3-dipolar cycloaddition of 2-nitrobenzothiophenes and isatin-derived azomethine ylides with a bifunctional hydrogen-bonding thiourea catalyst was established, giving polyheterocyclic compounds in excellent results (up to 99% yield, >20:1 dr for all cases and up to 99% ee). The enantioselectivity could be reversed by the bifunctional hydrogen-bonding squaramide catalyst containing the same chiral source as in the thiourea catalyst. DFT calculations revealed the origin of the observed stereochemistry and the reversal of enantioselectivity.

BENZOTHIOPHENE INHIBITORS OF RHO KINASE

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Azabicyclic inhibitors of serotonin reuptake

This invention provides 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]oct-2-enes and 3-(bicyclic heteroaryl)-8-azabicyclo[3.2.1]octanes of furmula (I) which are useful for the inhibition of serotonin reuptake in mammals. whereA-B is -C=CH- or -CH-CH2/s