153034-94-7

Basic information

• Product Name: 2-Fluoro-4-iodo-5-picoline
• Synonyms: 2-Fluoro-4-iodo-5-methylpyridine;2-FLUORO-4-IODO-5-PICOLINE;6-Fluoro-4-iodo-b-picoline;2-FLUORO-4-IODO-5-PICOLINE (2-FLUORO-4-IODO-5-METHYLPYRIDINE);6-Fluoro-4-iodo-3-picoline;2-Fluoro-4-iodo-5-methylpyridine≥ 99% (GC)
• CAS NO: 153034-94-7
• Molecular Formula: C₆H₅FIN
• Molecular Weight: 237.01
• Product Categories: Fluorin-contained pyridine series;Pyridine;Heterocycle;Pyridines;Boronic Acid;Building Blocks;C6;Chemical Synthesis;Heterocyclic Building Blocks;New Products for Chemical Synthesis
• Mol File: 153034-94-7.mol

Chemical Properties

• Melting Point: 40-45℃
• Boiling Point: 244.343 °C at 760 mmHg
• Flash Point: >110°C
• Appearance: Off-white/Solid
• Density: 1.893 g/cm³
• Vapor Pressure: 0.048mmHg at 25°C
• Refractive Index: 1.587
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• Solubility: soluble in Methanol
• PKA: -1.53±0.18(Predicted)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 2-Fluoro-4-iodo-5-picoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Fluoro-4-iodo-5-picoline(153034-94-7)
• EPA Substance Registry System: 2-Fluoro-4-iodo-5-picoline(153034-94-7)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-22
• Safety Statements: 26-36-36/39
• WGK Germany: 3
• Hazardous Substances Data: 153034-94-7(Hazardous Substances Data)

Usage

Chemical Properties

crystals

InChI:InChI=1/C6H5FIN/c1-4-3-9-6(7)2-5(4)8/h2-3H,1H3

Upstream product

• 153034-78-7 2-Fluoro-3-iodo-5-methylpyridine 
• 2369-19-9 2-fluoro-5-methylpyridine 

Downstream Products

• 450840-65-0 4-(3-chlorophenyl)-2-fluoro-5-methylpyridine 
• 777096-61-4 2-fluoro-5-methyl-4-(3-trifluoromethyl-phenyl)-pyridine 
• 777096-60-3 4-(3,5-dichloro-phenyl)-2-fluoro-5-methyl-pyridine 
• 450840-75-2 4-(3-chlorophenyl)-5-methyl-2-pyridinecarbonitrile 
• 450840-70-7 5-(bromomethyl)-4-(3-chlorophenyl)-2-fluoropyridine 
• 777096-62-5 4-(3,5-dichloro-phenyl)-5-methyl-pyridine-2-carbonitrile 
• 777096-64-7 4-(3-chloro-phenyl)-5-methyl-6-oxo-1,6-dihydro-pyridine-2-carbonitrile 
• 777096-67-0 4-(3-chloro-phenyl)-1,5-dimethyl-6-oxo-1,6-dihydro-pyridine-2-carbonitrile 
• 777096-63-6 5-methyl-4-(3-trifluoromethyl-phenyl)-pyridine-2-carbonitrile 
• 777096-65-8 4-(3,5-dichloro-phenyl)-5-methyl-6-oxo-1,6-dihydro-pyridine-2-carbonitrile 
• 777096-68-1 4-(3,5-dichloro-phenyl)-1,5-dimethyl-6-oxo-1,6-dihydro-pyridine-2-carbonitrile 
• 777096-69-2 1,5-dimethyl-6-oxo-4-(3-trifluoromethyl-phenyl)-1,6-dihydro-pyridine-2-carbonitrile 
• 777096-66-9 5-methyl-6-oxo-4-(3-trifluoromethyl-phenyl)-1,6-dihydro-pyridine-2-carbonitrile 
• 450837-14-6 4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile 

Relevant articles and documents

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Synthesis of 1H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors

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Farnesyltransferase inhibitors

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First Metalation of Aryl Iodides: Directed Ortho-Lithiation of Iodopyridines, Halogen-Dance, and Application to Synthesis

Metalation of iodopyridines was succesfully achieved by LDA at low temperature.In many cases, lithiation is ortho directed by the iodo group which subsequently ortho-migrates very fast to give stabilized iodolithiopyridines.This procedure was applied to 2