153507-24-5Relevant articles and documents
Iodine as an efficient and available activator of sodium and potassium halides in carbon dioxide addition to epoxides
Chowdhury, B.,Lyubimov, S. E.,Zvinchuk, A. A.
, p. 1324 - 1327 (2021/08/10)
Sodium and potassium halides in combination with molecular iodine are efficient catalysts for the solvent-free addition of CO2 (10–56 atm) to epoxides giving organic carbonates.
Design, synthesis, and biological evaluation of tetra-substituted thiophenes as inhibitors of p38α MAPK
Vinh, Natalie B.,Devine, Shane M.,Munoz, Lenka,Ryan, Renae M.,Wang, Bing H.,Krum, Henry,Chalmers, David K.,Simpson, Jamie S.,Scammells, Peter J.
, p. 56 - 64 (2015/03/04)
p38α mitogen-activated protein kinase (MAPK) plays a role in several cellular processes and consequently has been a therapeutic target in inflammatory diseases, cancer, and cardiovascular disease. A number of known p38α MAPK inhibitors contain vicinal 4-fluorophenyl/4-pyridyl rings connected to either a 5- or 6-membered heterocycle. In this study, a small library of substituted thiophene-based compounds bearing the vicinal 4-fluorophenyl/4-pyridyl rings was designed using computational docking as a visualisation tool. Compounds were synthesised and evaluated in a fluorescence polarisation binding assay. The synthesised analogues had a higher binding affinity to the active phosphorylated form of p38α MAPK than the inactive nonphosphorylated form of the protein. 4-(2-(4-fluorophenyl)thiophen-3-yl)pyridine had a Ki value of 0.6 μm to active p38α MAPK highlighting that substitution of the core ring to a thiophene retains affinity to the enzyme and can be utilised in p38α MAPK inhibitors. This compound was further elaborated using a substituted phenyl ring in order to probe the second hydrophobic pocket. Many of these analogues exhibited low micromolar affinity to active p38α MAPK. The suppression of neonatal rat fibroblast collagen synthesis was also observed suggesting that further development of these compounds may lead to potential therapeutics having cardioprotective properties.
Design of visible-light photocatalysts by coupling of narrow bandgap semiconductors and TiO2: Effect of their relative energy band positions on the photocatalytic efficiency
Rawal, Sher Bahadur,Bera, Sandipan,Lee, Daeki,Jang, Du-Jeon,Lee, Wan In
, p. 1822 - 1830 (2013/08/23)
According to relative energy band positions between TiO2 and visible-light-absorbing semiconductors, three different types of heterojunction were designed, and their visible-light photocatalytic efficiencies were analyzed. In Type-A heterojunct
Spectrophotometric determination of the formation constant of triiodide ions in aqueous-organic solvent or polymer mixed media both in absence and presence of a surfactant
Naorem, Homendra,Devi, Seram Dushila
, p. 67 - 73 (2013/02/22)
The formation constant of triiodide ions from iodine-iodide equilibrium in aqueous-organic solvent or polymer mixed media have been determined spectrophotometrically at three different temperatures 20, 30 and 40 °C. The organic solvents chosen for the study are ethylene glycol, 2-methoxy ethanol, and 2-ethoxy ethanol while the polymers include polyethylene glycol (PEG), hydroxypropyl cellulose (HPC) or polyethylene oxide (PEO). Effect of a surfactant on the formation of triiodide ions in the mixed media has also been investigated. Though presence of the organic solvents led to an increase in the triiodide formation except for 2-ethoxy ethanol mixed media at low percentage, the increase in presence of PEG or the other polymer mixed media even at very low percentage was much higher as compared to those in ethylene glycol or its homologues. The increase in the formation constant has been discussed in terms of changes in its solvation properties and the hydrophobic character of the mixed media besides the solvent dielectric effects. The sharp increase in triiodide formation in presence of the polymer under study suggests the possibility of iodine being present as triiodide or other higher polyiodides in the inclusion complexes of iodine with other polymers like starch or PVA. The decrease in the triiodide formation in presence of surfactant micelles may, however, be attributed to solubilization of iodine by the micelles. Iodine was found to be better solubilized in TX-100 micelles as compared to SDS micelles.
Preparation of 2' , 6' -di-pyrazolyl-pyridine containing a reactive group R in 4' position
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Page/Page column 5, (2009/06/27)
The invention relates to the preparation of 2',6'-di-pyrazolyl-pyridin containing a reactive group R in 4' position and it's derivates. 2',6'-di-pyrazolyl-pyridin is prepared by reaction of (i) 2',6'-di-pyrazolyl-pyridine containing said reactive group in
Hydrothermal synthesis, characterization, photocatalytic activity and dye-sensitized solar cell performance of mesoporous anatase TiO2 nanopowders
Pavasupree, Sorapong,Jitputti, Jaturong,Ngamsinlapasathian, Supachai,Yoshikawa, Susumu
, p. 149 - 157 (2008/10/09)
Mesoporous anatase TiO2 nanopowder was synthesized by hydrothermal method at 130 °C for 12 h. The samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), selected-area electron diffraction (SAED), HRTEM, and Brunauer-Emmett-Teller (BET) surface area. The as-synthesized sample with narrow pore size distribution had average pore diameter about 3-4 nm. The specific BET surface area of the as-synthesized sample was about 193 m2/g. Mesoporous anatase TiO2 nanopowders (prepared by this study) showed higher photocatalytic activity than the nanorods TiO2, nanofibers TiO2 mesoporous TiO2, and commercial TiO2 nanoparticles (P-25, JRC-01, and JRC-03). The solar energy conversion efficiency (η) of the cell using the mesoporous anatase TiO2 was about 6.30% with the short-circuit current density (Jsc) of 13.28 mA/cm2, the open-circuit voltage (Voc) of 0.702 V and the fill factor (ff) of 0.676; while η of the cell using P-25 reached 5.82% with Jsc of 12.74 mA/cm2, Voc of 0.704 V and ff of 0.649.
Effects of amine fluoride cleaning chemistry on metallic aluminum IC films: II. Determining causal chemistry of OCPs by a time-dependent free energy relationship
Carter, Melvin Keith
, p. B30-B38 (2008/10/09)
A mathematical expression has been developed describing the change in thermodynamic free energy for a chemical system as a function of time to aid the interpretation of experimental time-dependent energy curves, such as the open circuit potential (OCP) plots, generated in corrosion studies. Accurate results of chemical potentials and reaction rates, one pair of constants for each causal chemical reaction, were found. Reaction rate constants were determined for OCPs of Fe(CN)64- + 1/2I2 → Fe(CN) 63- + I- at room temperature of ω1 = 0.011 ± 0.002/s, for oxidation of Fe(CN) 64- to Fe(CN)63- and ω2 = 0.108 + 0.003/s for reduction of I2 to I -, and the known half-cell potentials were reproduced. Experimental aluminum dissolution OCP data was fit using regression analysis describing a four to ten chemical reaction model. The formalism was useful in describing results of OCP plots of integrated circuits (IC) interconnect metals, cleaned by fluoride-based silicon wafer remover formulas, in terms of identifying the causal corrosion chemistry.
