15417-04-6Relevant articles and documents
Novel synthetic analogs of the Pseudomonas autoinducer
Kline,Bowman,Iglewski,De Kievit,Kakai,Passador
, p. 3447 - 3452 (2007/10/03)
Release of virulence factors in Pseudomonas aeruginosa is regulated by two N-acylhomoserine lactones, PAI-1 and PAI-2, that activate the respective transcription factors LasR and Rh1R. With the goal of developing novel therapeutic agents, we synthesized constrained analogs of PAI-1 and evaluated them in P. aeruginosa. Two of the novel analogs bound to LasR and showed agonist activity in LasR stimulation of a lasI-lacZ reporter construct.