101084-39-3

Basic information

• Product Name: 3-BROMO-2-METHOXYBENZOIC ACID 97
• Synonyms: 3-BROMO-2-METHOXYBENZOIC ACID 97;3-Bromo-2-methoxybenzoic acid 97%;3-BROMO-2-METHOXYBENZOIC
• CAS NO: 101084-39-3
• Molecular Formula: C₈H₇BrO₃
• Molecular Weight: 231.0443
• Product Categories: blocks;Bromides;Carboxes;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;C8;Carbonyl Compounds;Carboxylic Acids;Building Blocks;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks
• Mol File: 101084-39-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 121-123
• Boiling Point: 327.6 °C at 760 mmHg
• Flash Point: 151.9 °C
• Appearance: /
• Density: 1.625 g/cm³
• Vapor Pressure: 8.11E-05mmHg at 25°C
• Storage Temp.: Keep Cold
• Solubility: soluble in Methanol
• PKA: 3.70±0.10(Predicted)
• CAS DataBase Reference: 3-BROMO-2-METHOXYBENZOIC ACID 97(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-2-METHOXYBENZOIC ACID 97(101084-39-3)
• EPA Substance Registry System: 3-BROMO-2-METHOXYBENZOIC ACID 97(101084-39-3)

Safety Data

• Hazard Codes: Xi,T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 101084-39-3(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-methoxybenzoic acid 97 is a chemical compound that is commonly used in the field of organic synthesis. It is a white crystalline solid with a molecular formula of C8H7BrO3. 3-BROMO-2-METHOXYBENZOIC ACID 97 is often utilized as a building block in the production of pharmaceuticals, agrochemicals, and other organic compounds. It is important to handle this chemical with care, as it may be harmful if it comes into contact with the skin, eyes, or respiratory system. Additionally, it should be stored in a cool, dry place away from heat and light to maintain its stability and purity.

InChI:InChI=1/C8H7BrO3/c1-12-7-5(8(10)11)3-2-4-6(7)9/h2-4H,1H3,(H,10,11)/p-1

Upstream product

• 93292-77-4 (E)-3-Bromo-2-methoxy-1-prop-1-enylbenzene 
• 579-75-9 2-Methoxybenzoic acid 
• 260806-90-4 methyl 3-bromo-2-methoxybenzoate 
• 3883-95-2 3-bromosalicylic acid 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 260806-90-4 methyl 3-bromo-2-methoxybenzoate 
• 1273599-65-7 6-bromo-7-methoxy-2,3-dihydro-1H-inden-1-one 
• 1044256-82-7 1-azidomethyl-3-bromo-2-methoxy-benzene 
• 1201662-79-4 3,5-dichloro-N-((4'-chloro-2-methoxybiphenyl-3-yl)methyl)-N-(4-fluorobenzyl)-2-hydroxybenzenesulfonamide 
• 1201663-92-4 1-(4'-chloro-2-methoxybiphenyl-3-yl)-N-(4-fluorobenzyl)methanamine 
• 22256-43-5 2-methoxy-3-methylbenzoyl chloride 

Relevant articles and documents

A New Synthesis of 3-Bromo-2-methoxybenzoic Acid

A convenient preparation of 3-bromo-2-methoxybenzoic acid (8) from 2-bromophenol via 3-bromo-2-methoxy-1-(1-propenyl)benzene (11) is presented.

Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs

A series of compounds containing one or two salicylic acid moieties were synthesized, and their efficacy to inhibit the phosphohydrolase activity of PTP1B examined. Some of the methylenedisalicylic acid derivatives were potent inhibitors of PTP1B. Of those derivatives, 3c exhibited about a 14-fold selectivity against TC-PTP, and this compound was tested in a mouse model for its efficacy to prevent diet-induced obesity. It effectively suppressed the increases in body weight and adipose mass, without any noticeable toxic effect. The compound also prevented increases in the plasma triglyceride, cholesterol, and nonesterified fatty acid concentrations; thus, expanding its therapeutic potential to other related metabolic diseases, such as hyperlipidemia and hypercholesterolemia.

Directed ortho-metalation of unprotected benzoic acids. Methodology and regioselective synthesis of useful contiguously 3- and 6-substituted 2-methoxybenzoic acid building blocks

By treatment with s-BuLi/TMEDA at -78 °C, unprotected 2-methoxybenzoic acid is deprotonated exclusively in the position ortho to the carboxylate. A reversal of regioselectivity is observed when the acid is treated with n-BuLi/t-BuOK. These results are of general utility for the one-pot preparation of a variety of very simple 3- and 6-substituted 2-methoxybenzoic acids that are not easily accessible by conventional means. The potential usefulness of the method is demonstrated by the expedient synthesis of lunularic acid.