15480-00-9 Usage
Description
2-(2-Chlorophenoxy)ethanol, also known as 2-CPH, is a colorless liquid with a faint phenolic odor and belongs to the class of phenols. It is soluble in water and most organic solvents and is used as a solvent and synthetic intermediate in the production of various chemicals, including pharmaceuticals, pesticides, and dyes. Due to its potential to cause irritation to the skin, eyes, and respiratory system, as well as its harmful effects on aquatic life, it is important to handle 2-(2-Chlorophenoxy)ethanol with caution.
Uses
Used in Chemical Synthesis:
2-(2-Chlorophenoxy)ethanol is used as a synthetic intermediate for the production of various chemicals, including pharmaceuticals, pesticides, and dyes. Its versatility as a chemical building block allows for the creation of a wide range of compounds with diverse applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-(2-Chlorophenoxy)ethanol is used as a solvent and intermediate in the synthesis of various drugs. Its solubility in water and organic solvents makes it suitable for use in the formulation of medications.
Used in Pesticide Production:
2-(2-Chlorophenoxy)ethanol is employed in the manufacturing of pesticides, where it serves as a key component in the synthesis of active ingredients. Its use in this industry contributes to the development of effective pest control solutions.
Used in Dye Manufacturing:
In the dye industry, 2-(2-Chlorophenoxy)ethanol is utilized as a solvent and intermediate in the production of various dyes. Its properties make it suitable for use in the synthesis of dyes for textiles, plastics, and other applications.
Used in Solvent Applications:
Due to its solubility in water and most organic solvents, 2-(2-Chlorophenoxy)ethanol is used as a solvent in various industrial processes. Its ability to dissolve a wide range of substances makes it a valuable component in the production of various products.
Check Digit Verification of cas no
The CAS Registry Mumber 15480-00-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,4,8 and 0 respectively; the second part has 2 digits, 0 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 15480-00:
(7*1)+(6*5)+(5*4)+(4*8)+(3*0)+(2*0)+(1*0)=89
89 % 10 = 9
So 15480-00-9 is a valid CAS Registry Number.
InChI:InChI=1/C8H9ClO2/c9-7-3-1-2-4-8(7)11-6-5-10/h1-4,10H,5-6H2
15480-00-9Relevant articles and documents
Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi
Elhalem, Eleonora,Bailey, Brian N.,Docampo, Roberto,Ujváry, István,Szajnman, Sergio H.,Rodriguez, Juan B.
, p. 3984 - 3999 (2007/10/03)
As a continuation of our project aimed at the search for new and safe chemotherapeutic and chemoprophylactic agents against American trypanosomiasis (Chagas' disease), several drugs structurally related to 4-phenoxyphenoxyethyl thiocyanate (4) were designed, synthesized, and evaluated as antiproliferative agents against the parasite responsible for this disease, the hemoflagellated protozoan Trypanosoma cruzi. This thiocyanate derivative was previously shown to be an effective and potent agent against T. cruzi proliferation. Several drugs possessing thiocyanate groups proved to be effective growth inhibitors of T. cruzi growth. Among the designed compounds, it is important to point out the extremely potent activity shown by 11, 23, 38, 53, 90, 99, and 117 against the epimastigote forms of the parasite. All of them exhibited IC50 values in the low micromolar range, and these values were comparable with those presented by our lead drug 4 and ketokonazole, a well-known antiparasitic agent. The activity displayed by the nitrogen-containing derivative 90 was very promising with IC50 values of 3.3 μM. Several other thiocyanate derivatives also proved to be very potent inhibitors of the multiplication of T. cruzi epimastigotes, such as compounds 28, 33, 43, 48, 56, 61, 66, 71, 76, and 124. Compound 43 resulted in being a promising drug because it was also very effective against amastigotes, the clinically more relevant form of the parasite. This compound was 3-fold more potent than 4, while 11 showed nearly the same activity as our lead drug against intracellular T. cruzi. It was very surprising that the experimental juvenoid 124, although fairly devoid of activity against epimastigotes, was very effective against intracellular amastigotes growing in myoblasts. The rest of the designed compounds showed a broad degree of inhibitory action, from moderately active drugs to drugs almost devoid of antiparasitic activity. Compound 43 is an interesting example of an effective antichagasic agent that presents excellent prospectives not only as a lead drug but also to be used for further in vivo studies.
