2-(2-Chlorophenoxy)ethanol

Base Information

• Chemical Name: 2-(2-Chlorophenoxy)ethanol
• CAS No.: 15480-00-9
• Molecular Formula: C8H9 Cl O2
• Molecular Weight: 172.611
• Hs Code.: 2909499000
• European Community (EC) Number: 239-501-6,249-684-4
• DSSTox Substance ID: DTXSID1065897
• Nikkaji Number: J266.779G
• Wikidata: Q81992494
• Mol file: 15480-00-9.mol

Synonyms:2-(2-Chlorophenoxy)ethanol;15480-00-9;Ethanol, 2-(2-chlorophenoxy)-;2-(Chlorophenoxy)ethanol;2-(2-chlorophenoxy)ethan-1-ol;2-(2'-Chlorophenoxy)ethanol;EINECS 239-501-6;AI3-03886;29533-21-9;Ethanol, 2-(chlorophenoxy)-;2-(2-chloro-phenoxy)-ethanol;SCHEMBL2094937;DTXSID1065897;2-(2-hydroxyethoxy)-chlorobenzene;EINECS 249-684-4;MFCD00014034;AKOS000296224;AS-58922;FT-0608449;FT-0608450;F79755;J-009139

Chemical Property of 2-(2-Chlorophenoxy)ethanol

Chemical Property:

• Vapor Pressure: 0.00226mmHg at 25°C
• Melting Point: 107-108 °C
• Refractive Index: n20/D 1.553(lit.)
• Boiling Point: 276.8°Cat760mmHg
• PKA: 14.18±0.10(Predicted)
• Flash Point: 121.2°C
• PSA: 29.46000
• Density: 1.238g/cm³
• LogP: 1.71110
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 172.0291072
• Heavy Atom Count: 11
• Complexity: 108

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Chlorophenoxy)ethanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)OCCO)Cl

Technology Process of 2-(2-Chlorophenoxy)ethanol

There total 6 articles about 2-(2-Chlorophenoxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-[2-(2-chloro-phenoxy)-ethoxy]-tetrahydro-pyran (445283-19-2) → 2-(2-chlorophenoxy)ethanol (15480-00-9)

Guidance literature:

With methanol; pyridinium p-toluenesulfonate; at 20 ℃; for 16h;

DOI:10.1021/jm0201518

Reference yield: 43.0%

2-monochlorophenol (95-57-8) + 2-chloro-ethanol (107-07-3) → 2-(2-chlorophenoxy)ethanol (15480-00-9)

Guidance literature:

With sodium hydroxide; Heating; overnight;

DOI:10.1021/jo00135a018

Reference yield:

2-monochlorophenol (95-57-8) → 2-(2-chlorophenoxy)ethanol (15480-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: KOH / dimethylsulfoxide / 0.08 h / 20 °C

1.2: 23 percent / dimethylsulfoxide / 16 h / 20 °C

2.1: 97 percent / PPTs; MeOH / 16 h / 20 °C

With methanol; potassium hydroxide; pyridinium p-toluenesulfonate; In dimethyl sulfoxide;

DOI:10.1021/jm0201518

upstream raw materials:

oxirane

2-monochlorophenol

(2-chlorophenoxy)acetic acid

2-chloro-ethanol

Downstream raw materials:

me3Si(Oet-2-(Oph-2-Cl))

1-chloro-2-(2-chloroethoxy)-benzene

phosphoric acid mono-[2-(2-chloro-phenoxy)-ethyl ester]

[2-(2-chloro-phenoxy)-ethyl]-(tetra-O-acetyl-β-D-glucopyranoside)