15486-96-1Relevant articles and documents
Directing spatial disposition of ferrocene around homoadenine tetrads
Kumar, Jitendra,Purohit, Chandra Shekhar,Verma, Sandeep
, p. 2526 - 2528 (2008)
We report synthesis and crystallographic studies of a ferrocenyl conjugate of adenine, where the hydrogen bonding interactions promote and stabilize nucleobase homotetrad formation. The Royal Society of Chemistry.
Controlled generation of singlet oxygen by porphyrin-appended gold nanoparticles
Shinohara, Akira,Shinmori, Hideyuki
, p. 1341 - 1343 (2016)
Porphyrin-appended gold nanoparticles with different chain lengths were synthesized to examine the control over photosensitization. The efficiencies evaluated by singletoxygen generation were adjusted by the average number of porphyrins on one gold nanoparticle and the particle size regardless of the linker chain length between porphyrin site and gold core.
Lead derivatization of ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate and 5-bromo-2-(thiophene-2-carboxamido) benzoic acid as FabG inhibitors targeting ESKAPE pathogens
Varakala, Saiprasad Dasugari,Reshma, Rudraraju Srilakshmi,Schnell, Robert,Dharmarajan, Sriram
, (2021/11/26)
Our previous studies on FabG have identified two compounds 5-bromo-2-(thiophene-2-carboxamido) benzoic acid (A) and ethyl 6-bromo-2-((dimethylamino)methyl)-5-hydroxy-1-phenyl-1H-indole-3-carboxylate(B) as best hits with allosteric mode of inhibition. FabG is an integral part of bacterial fatty acid biosynthetic system FAS II shown to be an essential gene in most ESKAPE Pathogens. The current work is focussed on lead expansion of these two hit molecules which ended up with forty-three analogues (twenty-nine analogues from lead compound A and fourteen compounds from lead compound B). The enzyme inhibition studies revealed that compound 15 (effective against EcFabG, AbFabG, StFabG, MtFabG1) and 19 (inhibiting EcFabG and StFabG) had potency of broad-spectrum inhibition on FabG panel.
LIPIDS FOR LIPID NANOPARTICLE DELIVERY OF ACTIVE AGENTS
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Page/Page column 66; 79, (2020/07/25)
Compounds are provided having the following structure: (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein R1, R2, R3, R4, R5, L1, L2, L3, G1, G2, and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.
An Azo Coupling Strategy for Protein 3-Nitrotyrosine Derivatization
Liu, Yuxin,Zhou, Pengcheng,Da, Honghong,Jia, Huiyi,Bai, Feifei,Hu, Guodong,Zhang, Baoxin,Fang, Jianguo
supporting information, p. 11228 - 11232 (2019/08/07)
Herein, a strategy for the selective derivatization of 3-nitrotyrosine-containing proteins using the classic azo coupling reaction as the key step is described. This novel approach featured multiple advantages and was successfully applied to detect picomole levels of protein tyrosine nitration in biological samples.