1558-81-2Relevant articles and documents
Electrosynthesis of cyclopropane derivatives by a Perkin-type reaction
Petrosyan, V. A.,Vasil'ev, A. A.,Tatarinova, V. I.
, p. 84 - 88 (1994)
Electrolysis of active methylene compounds at a Pt cathode in MeCN in the presence of vicinal dihaloalkanes leads to cyclopropane derivatives in yields up to 90percent.In the cases of CH-acids with low pKa it is expedient to apply more active dihaloalkanes, while for CH-acids with higher pKa the desired product yields may be raised using electrogenerated bases. - Key words: CH-acids; 1,2-dihaloalkanes; cyclopropanes; electrosynthesis; electroreduction; electronegative bases; azobenzene.
Anionic ring-opening polymerization of alkyl 1- cyanocyclopropanecarboxylates
Kagumba, Lawino C.,Penelle, Jacques
, p. 4588 - 4594 (2005)
Poly(alkyl 1-cyanotrimethylene-1-carboxylate)s (CH2CH 2C(CN)(COOR))n are the next higher chain homologues of poly(α-cyanoacrylate)s. They were synthesized via the anionic ring-opening polymerization of the corresponding alkyl 1-cyanocyclopropanecarboxylate monomers initiated with thiophenolate salts (PhSM, with M = Li, Na, K, and NBu4) and at temperatures above 50°C. Precipitation of the growing polymer chains at an early stage during the polymerization did not prevent further propagation, probably via polymerization in the solid or at the solid surface. The propagating cyanoacetate carbanion is very stable in a normal air atmosphere, surviving for long periods of time in the absence of strong acids. Although monodisperse polymers were obtained in most experiments (M w/Mn + and NBu 4+ counterions were used. Nonquantitative initiations characterized polymerizations initiated by PhSLi and PhSNa. Attempted polymerizations of ethyl 1-cyanocyclobutanecarboxylate failed under similar or slightly more energetic experimental conditions, with the thiophenolate initiator attacking the pendant ester rather than the cyclic methylene group.
Synthesis, bioactivity, theoretical and molecular docking study of 1-cyano-N-substituted-cyclopropanecarboxamide as ketol-acid reductoisomerase inhibitor
Liu, Xing-Hai,Chen, Pei-Quan,Wang, Bao-Lei,Li, Yong-Hong,Wang, Su-Hua,Li, Zheng-Ming
, p. 3784 - 3788 (2007)
Ketol-acid reductoisomerase (KARI; EC 1.1.1.86) catalyzes the second common step in branched-chain amino acid biosynthesis. The catalyzed process consists of two stages, the first of which is an alkyl migration from one carbon atom to its neighbouring ato
CATHODIC SYNTHESIS OF CYCLOPROPANE DERIVATIVES BY THE ELECTROLYSIS OF COMPOUNDS WITH AN ACTIVATED METHYLENE GROUP IN 1,2-DICHLOROETHANE
Vasil'ev, A. A.,Tatarinova, V. I.,Petrosyan, V. A.
, p. 631 - 633 (1990)
The cathodic electrolysis of compounds with an activated methylene group in 1,2-dichloroethane leads to 1,1-disubstituted cyclopropanes.The current yield of these cyclopropane derivatives depends on the CH-acidity of the starting compounds and has a maximum at pKa ca.13.
A new synthesis of bicyclic N,O- and N,S-enaminals by the anionic cyclization of alk-4-ynals with amino alcohols and amino thiols
Gvozdev,Shavrin,Nefedov
, p. 409 - 415 (2014)
A reaction of alk-4-ynals with aliphatic amino alcohols or 2-aminoethanethiol in the system DMSO - KOH gives bicyclic N,O- and N,S-enaminals: 6-methylidenehexahydro-2H-pyrrolo[2,1-b][1,3]oxazines, 5-methylidenehexahydropyrrolo[2,1-b]oxazoles, or 5-methyl-
MACROCYCLIC COMPOUNDS AS STING AGONISTS AND METHODS AND USES THEREOF
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Paragraph 0306-0307, (2021/01/29)
Disclosed are macrocyclic compounds having the general Formula (I) or (II) and their tautomeric forms, stereoisomers, pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof, and their combination with suitable medicament, corresponding processes for the synthesis and pharmaceutical compositions and uses of compounds disclosed herein.
A class of chiral beta-hydroxyamide compounds, preparation method and applications thereof,
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Paragraph 0167; 0178, (2020/03/12)
The invention discloses a chiral beta-hydroxyamide compound and a preparation method thereof, wherein the compound is represented by a formula I. According to the invention, the raw material for preparing a non-natural chiral amino acid compound is obtained by carrying out catalytic hydrolysis on a prochiral diamide compound II with different substituents by using a Rhodococcus erythropolis AJ270microbial system, wherein the use amount of the Rhodococcus erythropolis can be adjusted according to the use amount of a substrate, the reaction solvent is a common buffer solution with the pH valueof 6.0-8.0, the temperature is 20-37 DEG C, the reaction time is 3-120 h, and the Rhodococcus erythropolis microbial catalytic system can be cultured through fermentation and conveniently stored; andwith the application of the biotransformation to prepare chiral monoamide carboxylic acid and dicarboxylic acid, the characteristics of simplicity and convenience in operation, high reaction efficiency, mild reaction conditions, high enantioselectivity, easiness in product separation and high product purity are achieved, and the application prospect is god.
Quinazolinone Compound and Application Thereof
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Paragraph 0760-0762, (2020/11/27)
The present invention relates to a series of quinazolinone compounds and applications thereof as PI3Kα inhibitors. In particular, the present invention relates to a compound shown in formula (I) and a tautomer or pharmaceutically acceptable salt thereof.
PARTIALLY SATURATED NITROGEN-CONTAINING HETEROCYCLIC COMPOUND
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Paragraph 0289; 0290, (2015/06/17)
There are provided compounds having a superior PHD2 inhibitory effect that are represented by general formula (I'): (in the above-mentioned general formula (I'), W, Y, R2, R3, R4, and Y4 are as described hereinabove), or pharmaceutically acceptable salts thereof.
NOVEL COMPOUNDS
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Page/Page column 66, (2015/12/17)
Disclosed are novel retinoid-related orphan receptor gamma (RORγ) modulators and their use in the treatment of diseases mediated by RORγ.
