6914-74-5

Usage

Chemical Properties

white to off-white powder

InChI:InChI=1/C5H7NO3/c6-3(7)5(1-2-5)4(8)9/h1-2H2,(H2,6,7)(H,8,9)

Upstream product

• 6914-75-6 Cyclopropan-1-carbonsaeureethylester-1-carbonsaeureamid 
• 1559-02-0 diethyl cyclopropane-1,1-dicarboxylate 
• 57-13-6 urea 
• 141-52-6 sodium ethanolate 
• 6914-71-2 dimethyl 1,1-cyclopropanedicarboxylate 
• 6914-79-0 1-cyano-cyclopropanecarboxylic acid 
• 6914-73-4 methyl 1-cyanocyclopropanecarboxylate 
• 1558-81-2 1-carbethoxy-1-cyanocyclopropane 

Downstream Products

• 630412-58-7 cyclopropane-1,1-dicarboxylic acid amide [4-(3-fluorobenzyloxy)phenyl]amide 
• 630413-43-3 cyclopropane-1,1-dicarboxylic acid amide [2-fluoro-4-(4-fluorobenzyloxy)phenyl]amide 
• 1026701-35-8 N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)[(2S)-2-methylbutyl]amino]-2-hydroxy-1-(phenylmethyl)propyl]-1-cyclopropane-1,1-dicarboxamide 
• 712270-08-1 N₁-(2'-anilino-4,4'-bipyridin-2-yl)cyclopropane-1,1-dicarboxamide 
• 68781-13-5 α-amino-cyclopropanecarboxylic acid hydrochloride 
• 1001345-81-8 1-{1-[(pyrrolidin-1-yl)methyl]cyclopropyl}methanamine 
• 1208169-97-4 N¹-[3-({4-[(3-methylphenyl)amino]-5-oxo-5,6-dihydropyrido[4,3-d]pyrimidin-2-yl}amino)propyl]-1,1-cyclopropanedicarboxamide 
• 1026701-29-0 N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)(2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]-1-cyclopropane-1,1-dicarboxamide 
• 1026701-10-9 1-cyclopropane-N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino]-1-(phenylmethyl)propyl]-1,1-dicarboxamide 
• 1026701-44-9 N-[(1S,2R)-3-[(6-benzothiazolylsulfonyl)pentylamino]-2-hydroxy-1-(phenylmethyl)propyl]-1-cyclopropane-1,1-dicarboxamide 
• 1026701-24-5 1-cyclopropane-N-[(1S,2R)-2-hydroxy-3-[[(4-methoxyphenyl)sulfonyl]pentylamino]-1-(phenylmethyl)propyl]-1,1-dicarboxamide 
• 5813-85-4 cyclopropane-1,1-dicarboxylic acid amide [4-(3-fluoro-benzyloxy)-phenyl]-amide 
• 22059-21-8 aminocyclopropane-1-carboxylic acid 

Relevant academic research and scientific papers

Synthesis of 2,3-dihydro-1H-pyrrolo[1,2-a]benzimidazoles via the cyclopropyliminium rearrangement of substituted 2-cyclopropylbenzimidazoles

2-Cyclopropylbenzimidazole derivatives with various substituents in the small ring undergo cyclopropyliminium rearrangement into 2,3- dihydropyrrolobenzimidazoles substituted at positions 1, 2 or 3. The substrates containing a functional group in position 1 of the cyclopropane ring form products substituted at position 3. Substituents at position 2 in most cases lead to the formation of a mixture of isomers. The reaction can be directed to yield one of the isomers predominantly by varying the solvent polarity.

Process for the preparation of 1-aminocyclopropanecarboxylic acid hydrochloride

The present invention relates to a novel process for preparing 1-aminocyclopropanecarboxylic acid hydrochloride (ACC*HCl) of the formula STR1 ACC*HCl is prepared from a cyclopropane-1,1-dicarboxylic acid diester via an 1-aminocarbonylcyclopropanecarboxylic acid ester intermediate and an alkali metal salt or alkaline earth metal salt of 1-aminocarbonylcyclopropanecarboxylic acid. The process represents a simplification and gives improved product yields.

Stereochemical studies on the reactions catalyzed by the PLP-dependent enzyme 1-aminocyclopropane-1-carboxylate deaminase

The stereochemical course of 1-aminocyclopropane-1-carboxylate deaminase which catalyzes the fragmentation of the cyclopropane substrate to alpha -ketobutyrate and ammonia has been unraveled with the help of substrates stereospecifically labeled with deuterium and/or tritium, and this has afforded important information about the process occurring at the active site during enzymatic conversion.