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CAS

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1573000-33-5

(R)-3-([1,1’-biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride is a chiral compound featuring a biphenyl group connected to a 2-aminopropan-1-ol moiety, with the hydrochloride salt form. The (R) configuration denotes the absolute stereochemistry at the chiral center, which is crucial for its potential pharmaceutical applications. The presence of an amine and an alcohol functional group, common in drug molecules, along with the biphenyl group, suggests that this compound could have unique physicochemical and biological properties, making it a promising candidate for drug discovery and development.

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  • 1573000-33-5 Structure

  • Basic information

    1. Product Name: (R)-3-([1,1’-biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride
    2. Synonyms: (R)-3-([1,1’-biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride
    3. CAS NO:1573000-33-5
    4. Molecular Formula:
    5. Molecular Weight: 263.767
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1573000-33-5.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (R)-3-([1,1’-biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: (R)-3-([1,1’-biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride(1573000-33-5)
    11. EPA Substance Registry System: (R)-3-([1,1’-biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride(1573000-33-5)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1573000-33-5(Hazardous Substances Data)

1573000-33-5 Usage

Uses

Used in Pharmaceutical Industry:
(R)-3-([1,1’-biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride is used as a potential pharmaceutical agent for various applications due to its unique structure and functional groups. The amine and alcohol moieties can interact with biological targets, while the biphenyl group may provide specific properties that could be exploited for therapeutic purposes.
Used in Drug Discovery and Development:
In the field of drug discovery and development, (R)-3-([1,1’-biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride is used as a compound of interest for further research. Its chiral nature and the presence of pharmacophores make it a valuable starting point for the design and synthesis of new drugs targeting various diseases and conditions.
Used in Research and Development of Chiral Compounds:
(R)-3-([1,1’-biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride is also used in the research and development of chiral compounds, as understanding the effects of stereochemistry on biological activity is essential for the development of more effective and selective drugs. (R)-3-([1,1’-biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride's (R) configuration can provide insights into the role of stereochemistry in drug action and help guide the design of future chiral drug candidates.

Check Digit Verification of cas no

The CAS Registry Mumber 1573000-33-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,5,7,3,0,0 and 0 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1573000-33:
(9*1)+(8*5)+(7*7)+(6*3)+(5*0)+(4*0)+(3*0)+(2*3)+(1*3)=125
125 % 10 = 5
So 1573000-33-5 is a valid CAS Registry Number.

1573000-33-5Relevant articles and documents

Preparation method of (R)-2-(N-tertbutyloxycarbonylamino)biphenylpropanol

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, (2016/10/08)

The invention discloses a preparation method of (R)-2-(N-tertbutyloxycarbonylamino)biphenylpropanol represented by formula (I). The method comprises the following steps: carrying out an Erlenmeyer-Plochl cyclization reaction on biphenylcarboxaldehyde and N-acylglycine, hydrolyzing or alcoholyzing, and carrying out asymmetric hydrogenation to obtain (R)-N-acylbiphenylalanine or an ester thereof; and carrying out acid hydrolysis, reduction and amino protection on the (R)-N-acylbiphenylalanine or the ester thereof, or carrying out reduction, acid hydrolysis and amino protection on the (R)-N-acylbiphenylalanine or the ester thereof, or directly reducing the (R)-N-acylbiphenylalanine or the ester thereof in order to obtain the product (R)-2-(N-tertbutyloxycarbonylamino)biphenylpropanol. The product is a key intermediate of Sacubitril (AHU-377) which is one of a novel blood pressure reducing medicine LCZ696. The method has the advantages of easily available raw materials, and suitableness for industrial production.

NEW PROCESS

-

, (2015/08/04)

The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone.

NEW PROCESS

-

, (2014/03/25)

Provided is a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ -amino- δ -biphenyl- a -methylalkanoic acid, or acid ester, backbone.

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