1573000-28-8

Basic information

• Product Name: (S)-1-([1,1’-biphenyl]-4-yl)-3-chloropropan-2-ol
• Synonyms: (S)-1-([1,1’-biphenyl]-4-yl)-3-chloropropan-2-ol
• CAS NO: 1573000-28-8
• Molecular Weight: 246.737
• Mol File: 1573000-28-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 400.5±33.0 °C(Predicted)
• Density: 1.156±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (S)-1-([1,1’-biphenyl]-4-yl)-3-chloropropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-([1,1’-biphenyl]-4-yl)-3-chloropropan-2-ol(1573000-28-8)
• EPA Substance Registry System: (S)-1-([1,1’-biphenyl]-4-yl)-3-chloropropan-2-ol(1573000-28-8)

Safety Data

• Hazardous Substances Data: 1573000-28-8(Hazardous Substances Data)

Usage

General Description

(S)-1-([1,1’-biphenyl]-4-yl)-3-chloropropan-2-ol is a chiral compound with a molecular structure containing a 1,1’-biphenyl moiety, and a 3-chloropropan-2-ol moiety. It has potential applications in organic synthesis and pharmaceutical research due to its chiral nature and potential biological activity. The compound may be used as a building block for the synthesis of other chiral molecules, as well as in the development of new pharmaceuticals. It is important to note that as a chiral compound, (S)-1-([1,1’-biphenyl]-4-yl)-3-chloropropan-2-ol exists as two enantiomers which may have different biological activities and effects. Further research and testing are necessary to fully understand the properties and potential uses of this compound.

Upstream product

• 67843-74-7 (S)-epichlorohydrin 
• 92-66-0 4-bromo-1,1'-biphenyl 

Downstream Products

• 1573000-36-8 (1-([1,1‘-biphenyl]-4-yl)-3-chloropropan-2-yl)pyrrolidine-2,5-dione 
• 1573000-40-4 (R)-3-([1,1‘-biphenyl]-4-yl)-2-phthaloyl-chloropropan 
• 1573000-33-5 (R)-3-([1,1’-biphenyl]-4-yl)-2-aminopropan-1-ol hydrochloride 
• 1426129-50-1 N-[(1R)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid tert-butyl ester 
• 1038924-97-8 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrol-1-yl)-2-methyl pentanoate 
• 149709-62-6 α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate 
• 1639970-62-9 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-(2,5-dioxopyrrol-1-yl)-2-methylpentanoic acid 

Relevant articles and documents

Preparation method of

The preparation method comprises the following steps 1-11: Wherein. ROH (Formula X) is a chiral alcohol and the like, PG is a hydroxy protecting group, a compound of Formula VI and a compound of Formula V are the chiral auxiliary of the present invention. To the invention, the chiral auxiliary base ROH compound and the chiral alcohol X (Formula VI) are used for preparing the chiral auxiliary base-type compound of formula V IV and the compound of Formula XI, and the compound of formula IV can be prepared through three-step simple operation steps of chiral auxiliary base. Be applicable to industrial production.

Preparation method of key intermediate of LCZ-696

The invention provides a novel method for preparing a key intermediate (2R,4S)-5-(biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid of an anti-cardiac failure drug LCZ-696. The reaction route of the method is as follows: formula (shown in the description). According to the preparation method provided by the invention, the synthetic route is simple, the operation is simple and convenient, the cost is low and the implementation of industrial production is easy.

NEW PROCESS

The invention relates to a new enantioselective process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone.