16051-48-2Relevant articles and documents
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Nichols et al.
, p. 4255,4257 (1953)
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Twist,Baughan
, p. 15,16 (1955)
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Design, synthesis and study of nitrogen monoxide donors as potent hypolipidaemic and anti-inflammatory agents
Theodosis-Nobelos, Panagiotis,Papagiouvanis, Georgios,Pantelidou, Maria,Kourounakis, Panos N.,Athanasekou, Chrysoula,Rekka, Eleni A.
, (2020/01/11)
Inflammation and oxidative stress are involved in cardiovascular diseases. Nitrogen monoxide participates in the regulation of endothelial processes. Thus, derivatives of classic nonsteroidal anti-inflammatory drugs (NSAIDs), trolox or cinnamic acids esterified with 2-(nitrooxy)ethanol were designed and studied. It was found that the nitrogen monoxide (NO) releasing activity was comparable to that of S-nitroso-N-acetylpenicillamine. The nitrooxy derivatives decreased potently lipid indices in the plasma of hyperlipidaemic rats (30-85%). All compounds presented increased anti-inflammatory activity in vivo, inhibiting carrageenan-induced rat paw oedema as high as 76%, up to six times higher than that of the parent acids. Lipoxygenase inhibitory activity was significant for most of them, although the parent molecules exerted a minor effect (IC50 > 0.2 mM). Those compounds incorporating an antioxidant structure inhibited rat microsomal membrane lipid peroxidation strongly and possessed radical scavenging activity. These results indicated that the described compounds could act at different targets in multifactorial diseases, further limiting the possible adverse effects of drug combinations.
Nitrate NO donor type evodiamine derivatives with anti-tumor activity
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Paragraph 0025, (2016/10/31)
The invention relates to the field of natural medicines and medicinal chemistry and particularly relates to derivatives with modified 13-N of evodiamine. The invention discloses a preparation method of the 13-N nitrate NO donor substituted evodiamine derivatives and evaluation of the anti-tumor activity. The structure of the derivatives is shown in the specification, wherein R is (CH2)n, and n is an integer between 1 and 8.