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1638885-65-0

4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide

    Cas No: 1638885-65-0

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  • 1638885-65-0 Structure

  • Basic information

    1. Product Name: 4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide
    2. Synonyms:
    3. CAS NO:1638885-65-0
    4. Molecular Formula:
    5. Molecular Weight: 481.41
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1638885-65-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide(1638885-65-0)
    11. EPA Substance Registry System: 4-[1,1,3,3-tetradeuterated-(7-(6-cyano-5-(trifluoromethyl)pyridin-3-yl)-8-oxo-6-thioxo-5,7-diazaspiro[3.4]octan-5-yl)]-2-fluoro-N-methylbenzamide(1638885-65-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1638885-65-0(Hazardous Substances Data)

1638885-65-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1638885-65-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,3,8,8,8 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1638885-65:
(9*1)+(8*6)+(7*3)+(6*8)+(5*8)+(4*8)+(3*5)+(2*6)+(1*5)=230
230 % 10 = 0
So 1638885-65-0 is a valid CAS Registry Number.

1638885-65-0Downstream Products

1638885-65-0Relevant articles and documents

Design, synthesis, and biological evaluation of deuterated apalutamide with improved pharmacokinetic profiles

Pang, Xuehai,Wang, Yingwei,Chen, Yuanwei

, p. 2803 - 2806 (2017)

A series of deuterated apalutamide were designed and prepared. Compared to its prototype compound 18, deuterated analogues 19 and 21 showed obviously higher plasma concentrations and better PK parameters after oral administration in mice. In rats, N-trideuteromethyl compound 19 displayed 1.8-fold peak concentration (Cmax), and nearly doubled its drug exposure in plasma (AUC0–∞) compared to compound 18. Unsurprisingly, compounds 18 and 19 had similar affinity for AR in vitro. In summary, the deuteration strategy could obviously improve PK parameters of apalutamide.

IMIDAZOLE DIKETONE COMPOUND AND USE THEREOF

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Paragraph 0113; 0118; 0119, (2016/06/28)

Provided are imidazolidinedione compounds of formula (I), processes for preparation, uses and pharmaceutically compositions thereof. Said imidazolidinedione compounds possess androgen receptor antagonist activity and can be used for preventing and treating diseases and disorders related to androgen receptor, such as prostate cancer, alopecia, hair regeneration, acne and adolescent acne.

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