164225-42-7

Basic information

• Product Name: 1,3-Cyclobutanedicarboxylicacid,1-amino-(9CI)
• Synonyms: 1,3-Cyclobutanedicarboxylicacid,1-amino-(9CI)
• CAS NO: 164225-42-7
• Molecular Formula: C6H9NO4
• Molecular Weight: 159.13996
• Product Categories: CARBOXYLICACID
• Mol File: 164225-42-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Cyclobutanedicarboxylicacid,1-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Cyclobutanedicarboxylicacid,1-amino-(9CI)(164225-42-7)
• EPA Substance Registry System: 1,3-Cyclobutanedicarboxylicacid,1-amino-(9CI)(164225-42-7)

Safety Data

• Hazardous Substances Data: 164225-42-7(Hazardous Substances Data)

Usage

Structure

Cyclobutane ring with two carboxylic acid groups at carbons 1 and 3, and an amino group attached to carbon 1.

Functional groups

Carboxylic acid, amino group

Derivative

Cyclobutane carboxylic acid

Applications

a. Synthesis of various organic compounds
b. Building block in the pharmaceutical industry for the synthesis of new drugs and biologically active molecules
c. Medicinal chemistry
d. Organic synthesis
e. Drug discovery

Potential use

As a starting material for the development of new pharmaceuticals and biologically active molecules due to its unique structure and functional groups.

Upstream product

• 23761-23-1 3-oxocyclobutanecarboxylic acid 
• 161181-48-2 trans-1-(benzoylamino)-1-(pentamethylenecarbamoyl)cyclobutane-3-carboxylate 
• 161181-44-8 3-(benzoylamino)-3-(pentamethylenecarbamoyl)-1-(phenylsulfonyl)cyclobutane-1-carboxylic acid 
• 158786-83-5 cis-1-amino-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide 
• 158786-87-9 cis-1-(benzoylamino)-3-(phenylsulfonyl)cyclobutane-1-N,N-pentamethylenecarboxamide 
• 158786-79-9 N,N-Pentamethylene-cis-3-(phenylsulfonyl)-1-triazenocyclobutane-1-carboxamide 
• 161181-43-7 1-Azido-3-benzenesulfonyl-cyclobutanecarbonyl chloride 
• 117488-02-5 cis-1-Azido-N,N-pentamethylene-3-(phenylsulfonyl)cyclobutane-1-carboxamide 
• 166667-05-6 dimethyl cis-1-benzoylamino-3-(phenylsulfonyl)cyclobutane-1,3-dicarboxylate 
• 166666-97-3 dimethyl trans-1-azido-3-(phenylsulfonyl)cyclobutane-1,3-dicarboxylate 
• 117488-20-7 cis-1-Azido-3-(phenylsulfonyl)cyclobutane-1-carboxylic acid 
• 166666-96-2 trans 1-azido-3-(phenylsulfonyl)cyclobutane-1,3-dicarboxylic acid 
• 166667-18-1 methyl cis-1-benzoylamino-1-cyano-3-carboxylate 
• 166666-99-5 dimethyl trans-1-amino-3-(phenylsulfonyl)cyclobutane-1,3-dicarboxylate 

Relevant articles and documents

Synthesis, NMDA receptor antagonist activity, and anticonvulsant action of 1-aminocyclobutanecarboxylic acid derivatives

A range of cis- and trans-3-substituted 1-aminocyclobutane-1-carboxylic acids has been synthesized and evaluated for antagonism at excitatory amino acid receptor sites and for anticonvulsant activity. Potent and selective antagonist activity at N-methyl-D

Synthesis and Activity of a Potent N-Methyl-D-aspartic Acid Agonist, trans-1-Aminocyclobutane-1,3-dicarboxylic Acid, and Related Phosphonic and Carboxylic Acids

We report the synthesis of a series of 3-carboxy-, 3-(carboxymethyl)-, 3-(1o-phosphoalkenyl)-, and 3-(1o-phosphonoalkyl)-1-aminocyclobutane-1-carboxylic acids for evaluation as agonists or antagonists of neurotransmission at excitatory amino acid receptor

REGIOSPECIFIC ADDITIONS OF HYDRAZOIC ACID AND BENZYLAMINE TO 1-(ARYLSULFONYL)BICYCLOBUTANES. APPLICATION TO THE SYNTHESIS OF CIS AND TRANS 2,7-METHANOGLUTAMIC ACIDS

Addition of hydrazoic acid or benzylamine to 1-(arylsulfonyl)bicyclobutanes introduces the nitrogen nucleophile at position 3 of the derived cyclobutane, even when a carboxyl derivative is present at this position as a second activating group.Precursors o

Total Synthesis of Cyclobutane Amino Acids from Atelia herbert smithii

The syntheses of two amino acids from the seeds of the legume Atelia herbert smithii, 2,4-methanoproline and 2,4-methanoglutamic acid, are described.The synthesis of third amino acid, cis-1-amino-3-(hydroxymethyl)cyclobutanecarboxylic acid and subsequent