16681-70-2Relevant articles and documents
Novel synthetic approaches to (Trifluoromethyl)triazoles
Sibgatulin, Dmytriy A.,Bezdudny, Andrii V.,Mykhailiuk, Pavel K.,Voievoda, Nataliia M.,Kondratov, Ivan S.,Volochnyuk, Dmitry M.,Tolmachev, Andrey A.
, p. 1075 - 1077 (2010)
New synthetic procedures for the trifluoromethyl-substituted triazoles, 3-(trifluoromethyl)-4H-1,2,4-triazole and 4-(trifluoromethyl)-1H-1,2,3-triazole, have been elaborated. The target compounds were prepared from commercially available trifluoroacethydr
TRIAZOLE COMPOUNDS AS LIPOXYGENASE INHIBITORS
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Page/Page column 38, (2008/06/13)
There is provided compounds of formula (I) wherein W is an optionally substituted aryl or heteroaryl group, and pharmaceutically-acceptable salts thereof, which compounds are useful in the treatment of diseases in which inhibition of the activity of a lipoxygenase (e.g. 15- lipoxygenase) is desired and/or required, and particularly in the treatment of inflammation.
TRANSFORMATIONS OF SUBSTITUTED 5-AMINOPYRIMIDINES UNDER CONDITIONS OF THE DIAZOTIZATION
Nemeryuk, Michal P.,Sedov, Andrej L.,Safonova, Tamara S.,Cerny, Antonin,Krepelka, Jiri
, p. 215 - 233 (2007/10/02)
Reaction of nitrous acid with 4-substituted and 4,6-disubstituted 5-aminopyrimidines Ia-In produces 4-substituted and 4,5-disubstituted 1,2,3-triazoles IIa-IIv, resp.Under similar conditions, 2,5-diaminopyrimidines XIIa-XIId give N(7)-oxides of 2-amino-4-aralkylthiopyrimido-1,2,3-triazines XIIIa-XIIId, and 5-amino-4-chloropyrimidines In and X give 2-diazocyanoacetamides XIa and XIb, resp.Also described are syntheses of 5-formylaminopyrimidines XVa-XVg from glycine ethyl ester via sodium salt XVI.