167683-93-4

Basic information

• Product Name: 2-FLUORO-4-METHOXYPHENOL
• Synonyms: 2-FLUORO-4-METHOXYPHENOL;Phenol, 2-fluoro-4-methoxy- (9CI);2-Fluorohydroquinonemonomethylether(OH=1);3-Fluoro-4-hydroxyanisole;3-Fluoro-4-hydroxyanisole, 2-Fluoro-p-guaiacol
• CAS NO: 167683-93-4
• Molecular Formula: C₇H₇FO₂
• Molecular Weight: 142.13
• Product Categories: HALIDE;Aromatic Phenols;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Phenols
• Mol File: 167683-93-4.mol

Chemical Properties

• Boiling Point: 94°C/4mmHg
• Flash Point: 100.6 °C
• Appearance: /
• Density: 1.27
• Vapor Pressure: 0.235mmHg at 25°C
• Refractive Index: 1.5240-1.5280
• Storage Temp.: 2-8°C
• PKA: 9.19±0.18(Predicted)
• CAS DataBase Reference: 2-FLUORO-4-METHOXYPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-4-METHOXYPHENOL(167683-93-4)
• EPA Substance Registry System: 2-FLUORO-4-METHOXYPHENOL(167683-93-4)

Safety Data

• Hazard Codes: C
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 167683-93-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-FLUORO-4-METHOXYPHENOL is used as a chemical intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy and safety of existing medications.
Used in Agrochemical Industry:
2-FLUORO-4-METHOXYPHENOL is utilized as a key component in the production of agrochemicals, helping to create effective and environmentally friendly solutions for pest control and crop protection.
Used in Dye Manufacturing:
2-FLUORO-4-METHOXYPHENOL is employed as a raw material in the manufacturing of dyes, enabling the creation of a wide range of colors and improving the performance of dye products.
Used in Perfume Production:
2-FLUORO-4-METHOXYPHENOL is used as a component in the production of perfumes, contributing to the creation of unique and long-lasting fragrances.
Used in Organic Compound Synthesis:
2-FLUORO-4-METHOXYPHENOL serves as a versatile building block in the synthesis of various organic compounds, facilitating the development of new materials and chemical processes.

InChI:InChI=1/C7H7FO2/c1-10-5-2-3-7(9)6(8)4-5/h2-4,9H,1H3

Upstream product

• 181305-63-5 2-fluoro-4-methoxyphenyl acetate 
• 2105-94-4 4-bromo-2-fluorophenol 
• 124-41-4 sodium methylate 
• 74457-86-6 1-(2-fluoro-4-methoxyphenyl)-1-ethanone 
• 150-76-5 4-methoxy-phenol 
• 78646-39-6 2-(4-methoxyphenoxy)pyridine 
• 456-49-5 1-fluoro-3-methoxybenzene 

Downstream Products

• 1026793-94-1 2-ethoxy-1-fluoro-4-methoxybenzene 
• 550998-23-7 trifluoromethanesulfonic acid 2-fluoro-4-methoxyphenyl ester 
• 438497-28-0 2-fluoro-4-methoxy-[2-(trimethylsilyl)ethoxymethoxy]benzene 
• 936247-37-9 5-bromo-2-(2-fluoro-4-methoxy-phenoxy)-thiazole 
• 550998-24-8 2-(2-fluoro-4-methoxyphenyl)-6-methoxynaphthalene 
• 550997-89-2 6-(2-fluoro-4-hydroxyphenyl)-2-naphthol 
• 858946-69-7 3-(2-fluoro-4-methoxyphenyl)-7-methoxy-1-naphthonitrile 
• 634192-51-1 2-fluoro-4-methoxy-1,1'-biphenyl 
• 477860-13-2 2-fluoro-4-hydroxy-[1,1'-biphenyl] 
• 672931-52-1 ethyl 2-(2-fluoro-4-methoxyphenoxy)-2-methylpropionate 
• 1402593-38-7 N-cyclopropyl-4-{6-(2-fluoro-4-methoxyphenoxy)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-2-methylbenzamide 
• 1421365-72-1 C₂₂H₁₆ClFN₂O₃ 
• 1578263-70-3 C₂₀H₁₉FN₂O₄ 
• 1417996-86-1 C₈H₇FO₃ 

Relevant articles and documents

Synthetic method 4 - alkoxyphenol compounds

The invention discloses a synthetic method of 4 - alkoxyphenol compounds, and belongs to the field of organic chemical synthesis. The method is as follows: An aryl alkyl ether compound is added to the sealing tube. The catalyst dimerization acetic acid rhodium and the oxidizing agent iodobenzene diethyl ester are added, a solvent trifluoroacetic anhydride is added, and the 4 -alkoxyphenol compound is prepared by heating reaction. To the invention, high regioselectivity direct hydroxylation of the aryl alkyl ether compound is realized, the application range of the substrate is wide, the yield is high, the activity after amplification reaction does not significantly decay, and higher yield is still obtained. The utility model has good practicability and industrial application prospect.

Para -Selective hydroxylation of alkyl aryl ethers

para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(ii) catalyst, hypervalent iodine(iii) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile and efficient method for preparing clinical drugs monobenzone and pramocaine on a gram scale.

Synthesis of 2 - fluoro phenol compounds

The present invention provides a method for synthetizing a 2-fluoro phenol compound shown in a formula IV. The phenol compound shown in the formula I is prepared into a 2-pyridine oxygroup arene compound shown in a formula II through an Ullmann reaction, the 2-pyridine oxygroup arene compound shown in the formula II is mixed with a palladium catalyst, a fluorinating reagent, an additive and an organic solvent, the mixture is stirred under the temperature of 30-160 DEG C to perform a fluorination reaction to obtain an ortho-position fluoridated 2-pyridine oxygroup arene compound shown in a formula III, and the ortho-position fluoridated 2-pyridine oxygroup arene compound shown in the formula III is prepared into the 2-fluoro phenol compound shown in the formula IV through the action of alkali. The method provided by the present invention has the advantages of mild reaction conditions, simplicity in operations, good substrate adaptability, high fluorination selectivity and the like. The 2-fluoro phenol compound is shown in the figure below.

ERbeta ligands. Part 1: the discovery of ERbeta selective ligands which embrace the 4-hydroxy-biphenyl template.

The synthesis and structure-activity relationships of a series of simple biphenyls is described. Optimization of the 4-hydroxy-biphenyl template led to compounds with ERbeta selectivity on the order of 20-70-fold.

N-arylalkyl-N-heteroarylurea and guandine compounds and methods of treating HIV infection

A method for treating HIV which comprises a compound of the formula STR1 wherein A is STR2 and Zi is O, Se, NRa or C(Ra)2, and Zii is --O or (=O)2 ; wherein R1, R2, R3, and R4 are as defined in the specification.

Phenethylthiazolylthiourea (PETT) compounds as a new class of HIV-1 reverse transcriptase inhibitors. 2. Synthesis and further structure-activity relationship studies of PETT analogs

Phenylethylthiazolylthiourea (PETT) derivatives have been identified as a new series of nonnucleoside inhibitors of HIV-1 RT. Structure-activity relationship studies of this class of compounds resulted in the identification of N-[2-(2-pyridyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea hydrochloride (trovirdine; LY300046.HCl) as a highly potent anti-HIV-1 agent. Trovirdine is currently in phase one clinical trials for potential use in the treatment of AIDS. Extension of these structure-activity relationship studies to identify additional compounds in this series with improved properties is ongoing. A part of this work is described here. Replacement of the two aromatic moleties of the PETT compounds by various substituted or unsubstituted heteroaromatic rings was investigated. In addition, the effects of multiple substitution in the phenyl ring were also studied. The antiviral activities were determined on wild-type and constructed mutants of HIV-1 RT and on wild-type HIV-1 and mutant viruses derived thereof, Ile100 and Cys181, in cell culture assays. Some selected compounds were determined on double- mutant viruses, HIV-1 (Ile100/Asn103) and HIV-1 (Ile100/Cys181). A number of highly potent analogs were synthesized. These compounds displayed IC50's against wild-type RT between 0.6 and 5 nM. In cell culture, these agents inhibited wild-type HIV-1 with ED50's between I and 5 nM in MT-4 cells. In addition, these derivatives inhibited mutant HIV-1 RT (Ile 100) with IC50's between 20 and 50 nM and mutant HIV-1 RT (Cys 181) with IC50's between 4 and 10 nM, and in cell culture they inhibited mutant HIV-1 (Ile100) with ED50's between 9 and 100 nM and mutant HIV-1 (Cys181) with ED50's between 3 and 20 nM.