78646-39-6

Basic information

• Product Name: Pyridine, 2-(4-methoxyphenoxy)-
• CAS NO: 78646-39-6
• Molecular Formula: C12H11NO2
• Molecular Weight: 201.225
• Mol File: 78646-39-6.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Pyridine, 2-(4-methoxyphenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2-(4-methoxyphenoxy)-(78646-39-6)
• EPA Substance Registry System: Pyridine, 2-(4-methoxyphenoxy)-(78646-39-6)

Safety Data

• Hazardous Substances Data: 78646-39-6(Hazardous Substances Data)

Upstream product

• 109-04-6 2-bromo-pyridine 
• 150-76-5 4-methoxy-phenol 
• 4262-06-0 di-2-pyridyl sulfide 
• 5029-67-4 2-iodopyridine 
• 694-59-7 pyridine N-oxide 
• 109-09-1 2-chloropyridine 
• 142-08-5 2-hydroxypyridin 
• 100-66-3 methoxybenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 

Downstream Products

• 1301223-54-0 2-(4-(2-(pyrrolidin-1-yl)ethoxy)phenoxy)pyridine 
• 68464-71-1 4-(Pyridin-2-yloxy)-phenol 
• 167683-93-4 2-fluoro-4-methoxy-phenol 
• 1446517-46-9 (5-methoxy-2-(pyridin-2-yloxy)-1,3-phenylene)bis(phenylmethanone) 
• 35572-38-4 2-(4-methoxyphenyl)-1-phenylpropan-1-one 
• 120-44-5 1,4-di(4-methoxyphenyl)ethanone 
• 24845-40-7 2-(4-methoxyphenyl)acetophenone 
• 14311-78-5 (4-methoxyphenyl)dimethyl(phenyl)silane 
• 14311-79-6 (4-methoxyphenyl)(methyl)diphenylsilane 
• 2132-80-1 4,4'-Dimethoxybiphenyl 
• 14311-00-3 (4-methoxyphenyl)triphenylsilane 
• 59115-45-6 2-(4-methoxyphenyl)naphthalene 

Relevant articles and documents

Ruthenium-Catalyzed meta-CAr–H Bond Difluoroalkylation of 2-Phenoxypyridines

A ruthenium-catalyzed meta-selective CAr–H bond difluoroalkylation of 2-phenoxypyridine using 2-bromo-2,2-difluoroacetate has been developed. Mechanistic studies indicated that this difluoroalkylation might involve a radical process. Furthermore, a new method is reported for the synthesis of 2-(meta-difluoroalkylphenoxy)pyridine derivatives, which are present in many pharmaceuticals and other functional compounds.

Identification of an Oxalamide Ligand for Copper-Catalyzed C?O Couplings from a Pharmaceutical Compound Library

A typical pharmaceutical compound library is stocked with molecular diversity and could provide a platform for the discovery of new ligand structures. Herein, we describe the use of this approach in combination with high throughput screening to identify N,N’-bis(thiophene-2-ylmethyl)oxalamide as a ligand that is generally effective for copper-catalyzed C?O cross-couplings to prepare both biarylethers as well as phenols under mild conditions.

Chromium-Catalyzed Regioselective Kumada Arylative Cross-Coupling of C(aryl)-O Bonds with a Traceless Activation Strategy

We report here the chromium-catalyzed regioselective Kumada arylative cross-coupling of C(aryl)-O bonds at ambient temperature. By using a simple and low-cost chromium(II) chloride salt as a precatalyst, accompanied by a 2-pyridyl ligation, the catalytic cleavage and arylative coupling of C(aryl)-O bonds were achieved with a traceless activation strategy, overcoming the regioselectivity obstacle when several C-O bonds coexist in the Kumada coupling system.