16874-17-2

Basic information

• Product Name: (S)-3-PHENYLALANINE T-BUTYL ESTER
• Synonyms: (S)-3-PHENYLALANINE T-BUTYL ESTER;L-PHENYLALANINE-T-BUTYL ESTER;(S)-3-Phenylalaninetert-butylester;(2S)-2-Amino-3-phenylpropionic acid tert-butyl ester;L-Phenylalanine 1,1-dimethylethyl ester;L-Phenylalanine tert-butyl;L-Phe-OBut;Phenylalanine tert-butyl ester
• CAS NO: 16874-17-2
• Molecular Formula: C₁₃H₁₉NO₂
• Molecular Weight: 221.3
• Product Categories: Chiral Reagent
• Mol File: 16874-17-2.mol
• Article Data: 58

Chemical Properties

• Boiling Point: 336.9 °C at 760 mmHg
• Flash Point: 157.6 °C
• Appearance: /
• Density: 1.042±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 7.09±0.33(Predicted)
• CAS DataBase Reference: (S)-3-PHENYLALANINE T-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-PHENYLALANINE T-BUTYL ESTER(16874-17-2)
• EPA Substance Registry System: (S)-3-PHENYLALANINE T-BUTYL ESTER(16874-17-2)

Safety Data

• Hazardous Substances Data: 16874-17-2(Hazardous Substances Data)

Usage

General Description

(S)-3-Phenylalanine t-butyl ester is a chemical compound consisting of a t-butyl ester derivative of the amino acid (S)-3-phenylalanine. It is commonly used in organic synthesis and pharmaceutical research as a building block for the production of various biologically active compounds. The t-butyl ester group provides stability and protection to the phenylalanine residue, allowing for easy manipulation and manipulation in chemical reactions. (S)-3-PHENYLALANINE T-BUTYL ESTER is also used as a chiral building block in the synthesis of pharmaceutical drugs and as a key intermediate in the preparation of peptide-based drugs and materials. Additionally, it may have potential applications in the development of new drugs and materials due to its unique structural and chemical properties.

Upstream product

• 540-88-5 acetic acid tert-butyl ester 
• 673-06-3 D-(R)-phenylalanine 
• 188591-76-6 tert-butyl (2,2,2-trifluoroacetyl)-L-phenylalaninate 
• 112924-08-0 tert-butyl N-(benzyloxycarbonyl)-D-phenylalaninate 
• 99744-54-4 N-<2-<(Dimethyl)(phenyl)phosphonio>isopropyloxycarbonyl>-L-phenylalanin-tert-butylester-chlorid 
• 63-91-2 L-phenylalanine 
• 115-11-7 isobutene 
• 16881-34-8 N-benzyloxycarbonyl-L-phenylalanine t-butyl ester 
• 137451-52-6 (S)-2-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethanesulfonylamino)-3-phenyl-propionic acid tert-butyl ester 
• 83080-24-4 tert-butyl phenylpyruvate 
• 226900-30-7 tert-butyl 2-((diphenylmethylene)amino)-3-phenylpropanoate 
• 104505-09-1 [1,7,7-Trimethyl-bicyclo[2.2.1]hept-(2E)-ylideneamino]-acetic acid tert-butyl ester 
• 6456-74-2 Glycine tert-butyl ester 
• 2448-45-5 Cbz-D-Phe 

Downstream Products

• 22839-72-1 N-Benzyloxycarbonyl-β-O-benzyl-Asp-Phe-tert.-butylester 
• 101399-00-2 (S)-tert-butyl 2-(2-(((benzyloxy)carbonyl)amino)acetamido)-3-phenylpropanoate 
• 79432-19-2 Z-Ser-Phe-OBu^t 
• 34576-11-9 C₂₀H₂₂N₂O₄ 
• 189563-82-4 L-phenylalanine t-butyl ester N-hydroxysuccinimide carboxamide 
• 142319-73-1 N-[N-[(1,1-dimethylethoxy)carbonyl]-L-alanyl]-L-phenylalanine 1,1-dimethylethyl ester 
• 292061-19-9 N-benzyl-Phe-Ot-Bu 
• 660439-16-7 (2S,3R)-3-endo-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2-endo-carboxylic acid methyl ester 
• 660439-21-4 (2S,3R)-3-endo-(1-tert-butoxycarbonyl-2-phenyl-ethylcarbamoyl)bicyclo[2.2.1]hept-5-ene-2-endo-carboxylic acid benzyl ester 

Relevant articles and documents

Conformational rearrangements by water-soluble peptoid foldamers

Peptoids are a family of N-substituted glycine oligomers that are capable of forming stable helical structures. We seek peptoid monomers that can establish a strong folding propensity in aqueous conditions. Here we utilize L-phenylalanine tert-butyl ester

Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids

We report herein a Pd(II)/bis-sulfoxide-catalyzed intramolecular allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramolecular carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity.

Probe compounds for fluorescence recognition of amino acid enantiomers and synthesis and applications thereof

The invention provides probe compounds for fluorescence recognition of amino acid enantiomers. Probe compounds (a, b, c) are prepared by following steps: dissolving dimethyl squarate into anhydrous methanol, dropwise adding methanol solutions of phenylalanine ethyl ester, phenylalanine benzyl ester, and phenylalanine tert-butyl ester, after addition, stirring the solution for 20 to 24 hours at a room temperature, filtering the solution, and finally washing the filter residues by ethyl acetate several times. When D-proline is added into ethanol-water solutions of chiral probe compounds (a, c),the fluorescence strength of the solutions is reduced; when L-proline is added into the solutions, the fluorescence strength of the solutions is enhanced obviously; and thus the probe compounds (a,c)have a good recognition effect on two enantiomers of proline. When L-valine is added into ethanol-water solutions of the probe compound (b), the fluorescence strength of the solution is obviously reduced; when D-valine is added into the solution, the fluorescence strength of the solution is not changed; and thus the probe compound (b) has a good recognition effect on two enantiomers of valine.