16948-36-0

Basic information

• Product Name: H-D-Glu(Otbu)-OMe.HCL
• Synonyms: D-glutamic acid γ-tert·butylester α-methyl este;D-Glutamic acid 5-tert-butyl 1-methyl ester hydrochloride;(R)-5-tert-Butyl 1-methyl 2-aminopentanedioate hydrochloride;5-O-tert-butyl 1-O-methyl (2R)-2-aminopentanedioate
• CAS NO: 16948-36-0
• Molecular Formula: C10H19NO4.ClH
• Molecular Weight: 253.724
• Mol File: 16948-36-0.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: H-D-Glu(Otbu)-OMe.HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-D-Glu(Otbu)-OMe.HCL(16948-36-0)
• EPA Substance Registry System: H-D-Glu(Otbu)-OMe.HCL(16948-36-0)

Safety Data

• Hazardous Substances Data: 16948-36-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
H-D-Glu(Otbu)-OMe.HCl is used as a building block in peptide synthesis for the development of new pharmaceutical compounds. Its protective group allows for the controlled assembly of peptide chains, facilitating the creation of complex molecules with potential therapeutic applications.
Used in Scientific Research:
H-D-Glu(Otbu)-OMe.HCl is used as a reagent in various biochemical and biophysical studies. Its ability to integrate with other compounds makes it a valuable tool for investigating the structure and function of peptides and proteins, as well as their interactions with other molecules.
Used in Drug Delivery Systems:
H-D-Glu(Otbu)-OMe.HCl can be used as a component in the design of drug delivery systems, particularly for peptide-based therapeutics. Its protective group may help improve the stability and bioavailability of peptide drugs, enhancing their therapeutic efficacy and reducing potential side effects.

Upstream product

• 18635-51-3 5-(tert-butyl) 1-methyl (tert-butoxycarbonyl)-L-glutamate 
• 13726-84-6 Boc-Glu(OtBu)-OH 

Downstream Products

• 38155-01-0 Z-Lys(Boc)-Glu(OtBu)-OMe 
• 79640-68-9 α-methyl γ-tert-butyl N-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-L-glutamate 
• 95485-10-2 (S)-2-{4-[(4-Amino-2-formimidoylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester 1-methyl ester 
• 95485-11-3 (S)-2-{4-[(2-Amino-4-formimidoylamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid 5-tert-butyl ester 1-methyl ester 
• 73793-91-6 N-Hexadecanoyl-L-glutamic acid α-methyl ester 
• 35793-60-3 (R)-2-((S)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester 
• 4902-24-3 methyl ((benzyloxy)carbonyl)-L-valyl-L-(O-tert-butyl)glutamate 
• 35793-61-4 (S)-2-((R)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester 
• 35793-59-0 tert-butyl methyl (S,S)-2-(4-((tert-butyl)oxycarbonyl)-2-((phenylmethoxy)carbonylamino) butanoylamino)pentane-1,5-dioate 

Relevant articles and documents

Kinetic Selection in the Out-of-Equilibrium Autocatalytic Reaction Networks that Produce Macrocyclic Peptides

Autocatalytic reaction networks are instrumental for validating scenarios for the emergence of life on Earth and for synthesizing life de novo. Here, we demonstrate that dimeric thioesters of tripeptides with the general structure (Cys-Xxx-Gly-SEt)2 form strongly interconnected autocatalytic reaction networks that predominantly generate macrocyclic peptides up to 69 amino acids long. Some macrocycles of 6–12 amino acids were isolated from the product pool and were characterized by NMR spectroscopy and single-crystal X-ray analysis. We studied the autocatalytic formation of macrocycles in a flow reactor in the presence of acrylamide, whose conjugate addition to thiols served as a model “removal” reaction. These results indicate that even not template-assisted autocatalytic production combined with competing removal of molecular species in an open compartment could be a feasible route for selecting functional molecules during the pre-Darwinian stages of molecular evolution.