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5-tert-butyl 1-methyl N-[(benzyloxy)carbonyl]valylglutamate is a complex organic compound with the molecular formula C21H31NO6. It is a derivative of glutamic acid, an amino acid, and features a tert-butyl group, a methyl group, and a benzyloxycarbonyl (Cbz) protecting group. The Cbz group is commonly used in peptide synthesis to protect the amino group, preventing unwanted side reactions. 5-tert-butyl 1-methyl N-[(benzyloxy)carbonyl]valylglutamate is significant in the field of peptide chemistry, where it can be used as a building block for the synthesis of larger peptides and proteins. Its structure allows for controlled reactions and the formation of specific peptide bonds, which is crucial for the development of pharmaceuticals and bioactive molecules.

4902-24-3

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4902-24-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4902-24-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,9,0 and 2 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4902-24:
(6*4)+(5*9)+(4*0)+(3*2)+(2*2)+(1*4)=83
83 % 10 = 3
So 4902-24-3 is a valid CAS Registry Number.

4902-24-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-O-tert-butyl 1-O-methyl 2-[[3-methyl-2-(phenylmethoxycarbonylamino)butanoyl]amino]pentanedioate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4902-24-3 SDS

4902-24-3Downstream Products

4902-24-3Relevant academic research and scientific papers

Optimization and anti-cancer properties of fluoromethylketones as covalent inhibitors for ubiquitin C-terminal hydrolase L1

Chen, Hao,Das, Chittaranjan,Flaherty, Daniel P.,Galardy, Paul J.,Hewitt, Chad S.,Hussain, Sajjad,Imhoff, Ryan D.,Krabill, Aaron D.,Muli, Christine S.,Wendt, Michael K.

, (2021/05/31)

The deubiquitinating enzyme (DUB) UCHL1 is implicated in various disease states including neurodegenerative disease and cancer. However, there is a lack of quality probe molecules to gain a better understanding on UCHL1 biology. To this end a study was carried out to fully characterize and optimize the irreversible covalent UCHL1 inhibitor VAEFMK. Structure-activity relationship studies identified modifications to improve activity versus the target and a full cellular characterization was carried out for the first time with this scaffold. The studies produced a new inhibitor, 34, with an IC50 value of 7.7 μM against UCHL1 and no observable activity versus the closest related DUB UCHL3. The molecule was also capable of selectively inhibiting UCHL1 in cells and did not demonstrate any discernible off-target toxicity. Finally, the molecule was used for initial probe studies to assess the role of UCHL1 role in proliferation of myeloma cells and migration behavior in small cell lung cancer cells making 34 a new tool to be used in the biological evaluation of UCHL1.

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