16965-06-3

Basic information

• Product Name: BOC-LYS(TFA)-OH
• Synonyms: BOC-L-LYS(TFA)-OH;BOC-LYS(TFA)-OH;BOC-LYSINE(TFA)-OH;BOC-N-EPSILON-TRIFLUOROACETYL-L-LYSINE;BOC-N-EPSILON-TFA-L-LYSINE;N-ALPHA-BOC-N-EPSILON-TRIFLUOROACETYL-L-LYSINE;N-ALPHA-T-BUTYLOXYCARBONYL-N-EPSILON-TRIFLUORACETYL-L-LYSINE;N-ALPHA-T-BUTOXYCARBONYL-N-EPSILON-TRIFLUOROACETYL-L-LYSINE
• CAS NO: 16965-06-3
• Molecular Formula: C₁₃H₂₁F₃N₂O₅
• Molecular Weight: 342.31
• Product Categories: AMINOACIDS DERIVATIVES;Amino Acids
• Mol File: 16965-06-3.mol

Chemical Properties

• Melting Point: 102-105 °C
• Boiling Point: 485.585 °C at 760 mmHg
• Flash Point: 247.473 °C
• Appearance: White/Powder
• Density: 1.255 g/cm³
• Vapor Pressure: 9.25E-11mmHg at 25°C
• Refractive Index: 1.449
• Storage Temp.: -15°C
• Solubility: Soluble in DMSO.
• PKA: 3.97±0.21(Predicted)
• CAS DataBase Reference: BOC-LYS(TFA)-OH(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-LYS(TFA)-OH(16965-06-3)
• EPA Substance Registry System: BOC-LYS(TFA)-OH(16965-06-3)

Safety Data

• WGK Germany: 3
• F: 10-21
• HazardClass: IRRITANT
• Hazardous Substances Data: 16965-06-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
BOC-LYS(TFA)-OH is used as a building block for the synthesis of various organic molecules, including peptides, peptidomimetics, and other bioactive compounds. The Boc group serves as a temporary protecting group for the amino group, preventing unwanted side reactions during the synthesis process. The TFA group can be easily removed under mild acidic conditions, allowing for further functionalization of the molecule.
Used in Pharmaceutical Industry:
BOC-LYS(TFA)-OH is used as an intermediate in the development of new drugs and therapeutic agents. Its unique structure and functional groups make it a valuable component in the design and synthesis of novel pharmaceutical compounds with potential applications in various therapeutic areas, such as oncology, cardiovascular diseases, and neurological disorders.
Used in Chemical Research:
BOC-LYS(TFA)-OH is used as a research tool in the study of various chemical reactions and processes. Its reactivity and structural features make it an interesting subject for investigating new synthetic methods, reaction mechanisms, and the development of innovative chemical technologies.

InChI:InChI=1/C13H21F3N2O5/c1-12(2,3)23-11(22)18-8(9(19)20)6-4-5-7-17-10(21)13(14,15)16/h8H,4-7H2,1-3H3,(H,17,21)(H,18,22)(H,19,20)/t8-/m0/s1

Upstream product

• 383-64-2 S-ethyl trifluoroacetate 
• 13734-28-6 Boc-Lys-OH 
• 383-63-1 ethyl trifluoroacetate, 
• 24424-99-5 di-tert-butyl dicarbonate 
• 10009-20-8 (S)-6-trifluoroacetylamino-2-aminohexanoic acid 
• 84624-27-1 Boc-Lys(Fmoc)-OH 

Downstream Products

• 77829-75-5 C₂₀H₂₈F₃N₃O₅ 
• 1375701-67-9 α-N-Boc-ε-N-trifluoroacetyl-lysine-CBT 
• 1242276-50-1 C₂₇H₃₇F₃N₄O₅ 
• 34695-46-0 N-alpha-BOC-N-epsilon-TFA-lysine succinimidyl ester 
• 142824-66-6 Boc-Lys(COCF₃)-Lys(COCF₃)-Gly-OCH₂Ph 
• 142846-53-5 Boc-Lys(COCF₃)-Gly-OCH₂Ph 

Relevant articles and documents

Synthesis of a radioiodinated park nucleotide analog: A new tool for antibacterial screen development

The Park nucleotide is an important biological building block used in the construction of bacterial cell walls. Herein, we describe the synthesis of a radiolabeled Park nucleotide analog, p-iodophenoxyacyl-Ala-(D)-iso- GluLys-(D)-Ala-(D)-Ala-OH-[125

Control of lysyl oxidase activity through site-specific deuteration of lysine

Lysyl oxidase (LOX) is implicated in several extracellular matrix related disorders, including fibrosis and cancer. Methods of inhibition of LOX in vivo include antibodies, copper sequestration and toxic small molecules such as β-aminopropionitrile. Here,

THERAPIES FOR CANCER USING ISOTOPICALLY SUBSTITUTED LYSINE

Methods of treatment and substances for treatment of cancer may use or cause the creation of isotopically modified lysine at levels that do not occur naturally.

Reversible protection of lysine to facilitate the purification of protected peptide segments

The polarity of temporarily free lysine side chains can be exploited to aid in the purification of protected peptides. The amine groups can easily be reprotected after the purification step. Impurities in commercial TFE1 can cause trifluoroacetylation of free primary amines.