10009-20-8Relevant articles and documents
N-trifluoroacyl lysine derivatives in the synthesis of L-lysyl-L-glutamic acid
Cherevin,Gulevich,Popova,Zubreichuk,Knizhnikov
, p. 1427 - 1431 (2007)
Conditions were developed for simultaneous preparation of N a-trifluoroacetyl-L-lysine and N α,N a-bis(trifluoroacetyl)-L-lysine at overall conversion of initial lysine monohydrochloride up to 82%. By reaction of dimethyl L-glutamate with N α,N a-bis(trifluoroacetyl)-L-lysyl chloride in the presence of triethylamine or with N α- carboxyanhydride of N a-trifluoroacetyl-L-lysine with subsequent removing protecting groups in the formed dipeptides by treating with water-ethanol solution of sodium hydroxide we obtained L-lysyl-L-glutamic acid. Physicochemical characteristics of samples obtained coincided with characteristics of L-lysyl-L-glutamic acid described in the literature thus suggesting that no racemization occurred either at the stage of peptide bond formation or at deprotection.
THERAPIES FOR CANCER USING ISOTOPICALLY SUBSTITUTED LYSINE
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Page/Page column 7, (2009/10/22)
Methods of treatment and substances for treatment of cancer may use or cause the creation of isotopically modified lysine at levels that do not occur naturally.