17333-74-3

Basic information

• Product Name: 2-TOLUENEDIAZONIUM SALTS
• CAS NO: 17333-74-3
• Molecular Formula: C7H7N2^+Z−
• Molecular Weight: 119.146
• Mol File: 17333-74-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-TOLUENEDIAZONIUM SALTS (CAS DataBase Reference)
• NIST Chemistry Reference: 2-TOLUENEDIAZONIUM SALTS (17333-74-3)
• EPA Substance Registry System: 2-TOLUENEDIAZONIUM SALTS (17333-74-3)

Safety Data

• Safety Statements: Reaction with ammonium sulfide or hydrogen sulfide forms explosive products. When heated to decomposition they emit toxic fumes of NOsub xmlns="">x/sub>. See also other toluenediazonium compounds.
• Hazardous Substances Data: 17333-74-3(Hazardous Substances Data)

Upstream product

• 95-53-4 o-toluidine 

Downstream Products

• 59760-72-4 2-(2-methylphenylazo)-1,3-indandione 
• 6370-43-0 2-(2'-methylphenylazo)-4-methylphenol 
• 52288-41-2 2-hydroxy-3-o-tolyl-[1,4]naphthoquinone 
• 53815-21-7 1-o-tolyl-propane-1,2-dione-1-oxime 
• 13963-35-4 2-(phenylthio)toluene 
• 88-20-0 o-toluenesulfonic acid 
• 3969-57-1 o-tolylarsonic acid 
• 116600-40-9 toluene-2-diazonium ; triiodide 
• 584-90-7 2,2'-dimethylazobenzene 
• 529-27-1 2-methylphenylhydrazine 
• 4537-05-7 du-o-tolyl sulfide 
• 137-06-4 2-thiocresol 
• 74782-97-1 6-hydroxy-5-o-tolylazo-naphthalene-2-sulfonic acid 
• 82203-19-8 diethyl 2-(o-methylphenylhydrazono)-3-oxopentanedioate 

Relevant articles and documents

Identification of novel inhibitors of Aurora A with a 3-(pyrrolopyridin-2-yl)indazole scaffold

A novel series of 3-(pyrrolopyridin-2-yl)indazole derivatives were synthesized and biologically evaluated for their anti-proliferative effects on five human cancer cell lines. As a result, all of them exhibited vigorous potency against HL60 cell line with IC50 values ranging from singe digital nanomolar to micromolar level. Besides, a majority of them displayed modest to good antiproliferative activities against the other four cell lines, including KB, SMMC-7721, HCT116, and A549. Particularly, compound 2y, as the most distinguished one in this series, demonstrated IC50 values of 8.3 nM and 1.3 nM against HL60 and HCT116 cell lines, respectively. Afterwards, for exploring the molecular target, compounds2d, 2g and 2y were further selected to evaluate the inhibitory activities against a panel of kinases. Finally, they were identified to be targeting Aurora A kinase with significant selectivity over other kinases, such as CHK1, CDK2, MEK1, GSK3β, BRAF, IKKβ and PKC.