17334-08-6Relevant articles and documents
Co(II) complexes derived from (1-methyl-1H-imidazol-2-yl)methanol: Synthesis, characterization, spectroscopic study, DFT/TD-DFT calculations and biological evaluation
Benhassine, Anfel,Boulebd, Houssem,Anak, Barkahem,Ali, Mounira Kara,Bouraiou, Abdelmalek,Merazig, Hocine,Kacem-Chaouche, Noureddine,Belfaitah, Ali
, (2019)
We report in this paper, a combined experimental and theoretical study of two new Co(II) complexes [Co(OAc)2(L)2 (1) and CoCl2(L)2 (2)] based on (1-methyl-1H-imidazol-2-yl)methanol (L). The synthetized complexes were characterized by single-crystal X-ray diffraction, FT-IR and UV–Vis. spectroscopy. In complex 1, two molecules of L are coordinated to the Co(II) ion in bidentate mode through the nitrogen and oxygen atoms, displaying a hexa-coordinated compound in a distorted octahedral geometry, while in complex 2, L is ligated to the metal ion in monodentate fashion through the nitrogen atom exhibiting a distorted tetrahedron. The molecular geometries, electronic transitions and vibrational frequencies of the two complexes and L in the ground state were calculated using the global hybrid (B3LYP) and the range separated hybrid (CAM-B3LYP) density functional. The theoretical calculations are in good agreement with the experimental values. The ligand and its Co(II) complexes have been screened and evaluated for their potential as DPPH radical scavengers as well as antimicrobial agents against five pathogenic microorganisms such as Gram-positive and Gram-negative bacteria, a yeast and a fungus. The SAR study revealed that complex 1 exhibited the best antimicrobial effects and higher antioxidant activity than complex 2 and L.
Charge-Compensated Metallacarborane Building Blocks for Conjugation with Peptides
Frank, René,Ahrens, Verena M.,Boehnke, Solveig,Beck-Sickinger, Annette G.,Hey-Hawkins, Evamarie
, p. 308 - 317 (2016)
The cobalt bis(dicarbollide) complex [commo-3,3′-Co(1,2-C2B9H11)2]- has captured much attention in biochemical and medical contexts, in particular for the treatment of tumors by boron neutron capture therapy (BNCT). Derivatives of cobalt bis(dicarbollide) are commonly prepared through ring-opening reactions of cyclic oxonium ions, so the corresponding products are usually charged. Furthermore, attempts to incorporate cobalt bis(dicarbollide) into peptides are rare, despite obvious potential advantages. Here the synthesis of an imidazolium-based charge-compensated cobalt bis(dicarbollide) building block, which allows additional modifications with moieties of biochemical relevance, such as monosaccharides, is reported. Furthermore, conjugates of these building blocks with the Y1-receptor-selective derivative of neuropeptide Y ([F7,P34]-NPY) retained excellent response to hY1 receptors found to be overexpressed in breast tumors and metastases.
Efficient fixation of CO2 into organic carbonates catalyzed by 2-hydroxymethyl-functionalized ionic liquids
Wang, Jin-Quan,Cheng, Wei-Guo,Sun, Jian,Shi, Tian-Yuan,Zhang, Xiang-Ping,Zhang, Suo-Jiang
, p. 2360 - 2367 (2014)
Several novel 2-hydroxymethyl-functionalized ILs act as the catalysts for synthesis of cyclic carbonates from CO2 and epoxides without the use of any co-catalysts or organic solvent. Moreover, the 2-hydroxymethyl- functionalized ILs were compatible with base, which combined with K 2CO3 were used as effective catalytic system for green synthesis of dimethyl carbonate from CO2via ethylene carbonate without catalyst separation. Additionally, the mechanistic details of the fixation of CO2 into cyclic carbonate catalyzed by 2-hydroxymethyl-functionalized ILs were also elucidated by density functional theory. The process reported here represents a simple, ecologically safer, cost-effective and energy-saving route to organic carbonates from CO 2.
New Cd(II) complex derived from (1-methylimidazol-2-yl) methanol: Synthesis, crystal structure, spectroscopic study, DFT and TD-DFT calculations, antimicrobial activity and free-radical scavenging capacity
Belfaitah, Ali,Bencharif, Mustapha,Benhassine, Anfel,Chouiter, Mohamed Imed,Kacem-Chaouche, Noureddine,Kara Ali, Mounira,Merazig, Hocine
, (2022/02/25)
A combined experimental and theoretical study of new complex with a formula of [Cd(Hmim)2(OAc)2], where Hmim stands for (1-methyl-1H-imidazol-2-yl) methanol has been reported. The complex was characterized by single-crystal X-ray diffraction, elemental analysis, FT-IR and UV-vis spectroscopy. The crystal structure of the complex shows that two Hmim and two carboxylate groups are coordinated to the Cd(II) ion in monodentate fashion through the nitrogen and carboxylic oxygen atoms displaying a distorted tetrahedral geometry. Detailed theoretical studies were performed using DFT and TD-DFT calculations, other properties such as chemical bonding analysis (QTAIM, RDG, DOS) have been also carried out and are in agreement with the experimental results. The ligand and its Cd(II) complex have been screened in vitro and evaluated for their potential as DPPH radical scavengers as well as antimicrobial agents against five pathogenic microorganisms such as Gram-positive and Gram-negative bacteria, a yeast and a fungus using the agar diffusion method. The SAR study showed that the free ligand exerts no inhibitory activity, except a moderate activity against the yeast, while the complex exhibits an antimicrobial activity more potent or similar to that of standard drugs against all selected microorganisms, and a moderate to interesting antioxidant potential compared to Vitamin C as control.
Ionic liquid which has a low cellulose decomposition efficiency
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Paragraph 0175; 0178; 0179; 0180, (2017/04/13)
The present invention refers to cellulose decomposition rate of low relates to ionic liquid, the present invention according to ionic liquids compatible ionic liquid and similar or its solubility with cellulose compared to as well as superior, has a remarkably decomposition rate of cellulose disintegration when they dissolve in an unique cellulose therefore, the problem that the components close to by the polyester copolymer. useful. (by machine translation)
