19225-92-4

Usage

Uses

Used in Chemical Synthesis:
2-(Chloromethyl)-1-methyl-1H-imidazole is utilized as a chemical intermediate for the production of various other compounds. Its unique structure allows it to be a key component in the synthesis of a range of chemical products, contributing to the versatility and functionality of the final products.
Used in Pharmaceutical Industry:
In the pharmaceutical sector, 2-(Chloromethyl)-1-methyl-1H-imidazole is employed as a building block for the development of new drugs. Its reactivity and structural properties make it a valuable asset in the creation of novel therapeutic agents, potentially leading to advancements in medicine and healthcare.
Used in Research and Development:
2-(Chloromethyl)-1-methyl-1H-imidazole is also used in research and development settings, where it serves as a model compound for studying the properties and reactions of imidazole derivatives. This helps scientists and researchers to better understand the behavior of similar compounds and to develop new methodologies and applications in the field of organic chemistry.

InChI:InChI=1/C5H7ClN2/c1-8-3-2-7-5(8)4-6/h2-3H,4H2,1H3

Upstream product

• 17334-08-6 1-methyl-2-hydroxymethylimidazole 
• 616-47-7 1-methyl-1H-imidazole 

Downstream Products

• 1739-84-0 1,2-dimethyl-1H-imidazole 
• 87786-06-9 2-(1-methyl-2-imidazolyl)ethylamine 
• 1024582-76-0 tert-butyl 5-(2-(3-((1-methyl-1H-imidazol-2-yl)methoxy)-phenyl)quinazolin-4-ylamino)-1H-indazole-1-carboxylate 
• 3984-53-0 2-Cyanmethyl-1-methyl-imidazol 
• 1579299-45-8 ClPh₂SnSCH(1-methylimidazol-2-yl)(3,5-dimethylpyrazol-1-yl) 
• 1458656-63-7 methyl 2-((S)-6-((R)-4-(2,6-dimethyl-4-((1-methyl-1H-imidazol-2-yl)methoxy)phenyl)-7-fluoro-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate 
• 156440-95-8 2-triphenylphosphonium-1-methyl-1H-imidazole chloride 
• 184773-04-4 C₄₈H₅₃N₆O₁₃PS₂ 
• 189153-32-0 Thiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2-cyano-ethyl) ester S-(1-methyl-1H-imidazol-2-ylmethyl) ester 
• 189144-44-3 Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2-cyano-ethyl) ester S-(1-methyl-1H-imidazol-2-ylmethyl) ester 
• 17334-08-6 1-methyl-2-hydroxymethylimidazole 

Relevant academic research and scientific papers

BICYCLIC INHIBITORS OF HISTONE DEACETYLASE

Provided herein are compounds of Formula I and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone deacetylases (HDAC).

2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG

The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which PARG activity is implicated.

SULPHONAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Disclosed are compounds having the general formula (I) as defined herein, the preparation thereof, and the use thereof for the prophylaxis or treatment of any disease involving a dysfunction associated with the orexin 2 receptor such as obesity, appetite or taste disorders including cachexia, anorexia and bulimia, diabetes, metabolic syndromes, vomiting and nausea, depression and anxiety, addictions, mood and behaviour disorders, schizophrenia, sleep disorders, restless legs syndrome, memory learning disorders, sexual and psychosexual dysfunctions, pain, visceral or neuropathic pain, hyperalgesia, allodynia, digestive disorders, irritable bowel syndrome, neuronal degenerescence, ischaemic or haemorrhagic attacks, Cushing's disease, Guillain-Barré syndrome, myotonic dystrophy, urinary incontinence, hyperthyroidism, pituitary function disorders, hypertension or hypotension.

IMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA-A RECEPTOR COMPLEX

This invention relates to novel imidazole derivatives of formula (I), pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.

Substituted thiazoles as immunoregulants

Thiazole derivatives have been made, for example, by reacting a 2-aryl-2,2-dialkoxyethylamine with an appropriately substituted aryl acetyl halide followed by treating the resulting amide with diphosphoryl pentasulfide. The thiazole derivatives are found to be effective immunoregulants.

5R,6S,8R-2-(1-Methyl-2-imidazolylmethylthio)-6-(1-hydroxyethyl)penem-3-carboxylic acid

There is disclosed the antibacterial 5R,6S,8R-2-(1-methyl-2-imidazolylmethylthio)-6-(1-hydroxyethyl)penem-3-carboxylic acid, its pharmaceutically acceptable salts and esters as well as compositions containing them and methods for their use.