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1738-87-0

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1738-87-0 Usage

Description

Z-LEU-ONP, a synthetic peptide derivative, is a chemical compound utilized in biochemical research as a substrate for the detection of protease activity. It features a fluorogenic leaving group, ortho-nitrophenol (ONP), which becomes highly fluorescent upon cleavage by specific proteases. This property enables the easy detection and quantification of protease activity, making Z-LEU-ONP a valuable tool for studying protease function, inhibition, and for screening potential drug candidates targeting proteases. Its application in laboratory settings aids in the better understanding of various disease processes, such as cancer, inflammation, and infections, and holds potential for drug development and medical diagnostics.
Usage:
Used in Biochemical Research:
Z-LEU-ONP is used as a substrate for the detection of protease activity due to its fluorogenic leaving group, ONP, which becomes highly fluorescent upon cleavage by specific proteases.
Used in Studying Protease Function and Inhibition:
Z-LEU-ONP is used as a tool for studying the function and inhibition of proteases, contributing to a better understanding of their roles in various biological processes.
Used in Screening Potential Drug Candidates:
Z-LEU-ONP is used as a screening agent for potential drug candidates targeting proteases, aiding in the development of new therapeutics.
Used in Disease Research:
Z-LEU-ONP is used in laboratory settings to study various disease processes, including cancer, inflammation, and infections, by monitoring the activity of proteases involved in these conditions.
Used in Drug Development and Medical Diagnostics:
Z-LEU-ONP is used in the development of drugs and medical diagnostics, leveraging its ability to detect and quantify protease activity for potential therapeutic and diagnostic applications.

Check Digit Verification of cas no

The CAS Registry Mumber 1738-87-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,7,3 and 8 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1738-87:
(6*1)+(5*7)+(4*3)+(3*8)+(2*8)+(1*7)=100
100 % 10 = 0
So 1738-87-0 is a valid CAS Registry Number.
InChI:InChI=1/C20H22N2O6/c1-14(2)12-18(21-20(24)27-13-15-6-4-3-5-7-15)19(23)28-17-10-8-16(9-11-17)22(25)26/h3-11,14,18H,12-13H2,1-2H3,(H,21,24)

1738-87-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (S)-4-Nitrophenyl 2-(((benzyloxy)carbonyl)amino)-4-methylpentanoate

1.2 Other means of identification

Product number -
Other names (4-nitrophenyl) (2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1738-87-0 SDS

1738-87-0Relevant articles and documents

Thermodynamic and (1)H NMR Study of Proton Complex Formation of Histidine-containing Cyclodipeptides in Aqueous Solution

Arena, Giuseppe,Impellizzeri, Giuseppe,Maccarrone, Giuseppe,Pappalardo, Giuseppe,Sciotto, Domenico,Rizzarelli, Enrico

, p. 371 - 376 (2007/10/02)

A thermodynamic and (1)H NMR study of proton complex formation in aqueous solution of some L-histidine-containing cyclic L-dipeptides has been carried out.The enthalpic and entropic changes associated with protonation of the cyclodipeptides, obtained by potentiometric and calorimetric measurements, together with the (1)H NMR data and NOESY experiments, enable the role played by non-covalent interactions in proton complex formation to be assessed.In addition, a comparison with c(Gly-His) permits the influence of side-chain residues on the conformation of protonated species to be observed.

A New Method for the Preparation of Active Esters Using Di-2-pyridyl Carbonate

Kim, Sunggak,Ko, Young Kwan

, p. 473 (2007/10/02)

The use of di-2-pyridyl carbonate in the presence of a catalytic amount of 4-dimethylaminopyridine is found to be very effective in the preparation of various active esters.

Psycho-pharmacological peptides

-

, (2008/06/13)

The present invention relates to novel psycho-pharmacological active peptides and peptide derivatives of the formula: wherein R represents the amino acid residue L-Lys or L-Arg, R1 represents the amino acid residue L-Glu or L-Gln, B represents one of the following amino acid or peptide-radicals: L-Leu-OH, (α-dehydro)Leu-OH D-Leu-OH L-Leu-L-Phe-OH L-Leu-L-Phe-L-Lys-OH L-MeLeu-OH or the radical STR1 and A represents one of the following radicals or residues: hydrogen H-L-Glu Z1 -L-Glu Z2 -L-Ser-L-Glu- H-Q1 -L-Thr-L-Ser-L-Glu- Q2 -L-Thr-L-Ser-L-Glu- Z3 -Q1 -L-Thr-L-Ser-L-Glu- or H2 N-ALK-CO-L-Phe-Q1 -L-Thr-L-Ser-L-Glu- in which Z1 represents H-L-Ser, H-D-Ser, desamino-Ser, 2,3-dihydroxy propanoyl or H2 N-ALK-CO-, Z2 represents H-L-Thr, H-D-Thr, desamino-Thr, 2,3-dihydroxybutanoyl or H2 N-ALK-CO; Q1 represents L-Met, L-Met(O), L-Met (O2) or L-Leu Q2 represents H-D-Met, H-D-Met (O), H-D-Leu, H-D-Met (O2), desamino Met, desamino Met (O), desamino Met (O2), desamino Leu, 2-hydroxy-4-methylthiobutanoyl, 2-hydroxy-4-methylpentanoyl or the radical H2 N-ALK-CO, Z3 represents H-L-Phe, H-D-Phe, desamino Phe, 2-hydroxy-3-phenyl-propanoyl and H2 N-ALK-CO-, and ALK represents an alkylene or alkylidene group with 1-6 carbon atoms, as well as the functional derivatives thereof.

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