174195-95-0

Basic information

• Product Name: Cyclopentanecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester
• CAS NO: 174195-95-0
• Molecular Formula: C10H16O3
• Mol File: 174195-95-0.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Cyclopentanecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopentanecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester(174195-95-0)
• EPA Substance Registry System: Cyclopentanecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester(174195-95-0)

Safety Data

• Hazardous Substances Data: 174195-95-0(Hazardous Substances Data)

Usage

General Description

Cyclopentanecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester is a chemical compound that is commonly known as tert-butyl cyclopentanone. It is an ester derivative of cyclopentanecarboxylic acid, and it is often used in the synthesis of pharmaceuticals and agrochemicals. Cyclopentanecarboxylic acid, 3-oxo-, 1,1-dimethylethyl ester is known for its pleasant, fruity odor and is used in the production of flavors and fragrances. It is also used as a solvent in various industrial applications. Additionally, tert-butyl cyclopentanone is known to have low toxicity and is considered to be relatively safe to handle and use.

Upstream product

• 98-78-2 3-Oxo-cyclopentanecarboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 
• 75-65-0 tert-butyl alcohol 
• 32811-75-9 methyl 3-oxocyclopentane-1-carboxylate 

Downstream Products

• 782493-18-9 (1S)-N-[2-tert-butoxy-5-(trifluoromethyl)benzyl]-1-isopropyl-3-oxocyclopentanecarboxamide 
• 782493-16-7 benzyl (1S)-1-isopropyl-3-oxocyclopentanecarboxylic acid 
• 693246-00-3 benzyl 1-isopropyl-3-oxocyclopentanecarboxylic acid 
• 782493-13-4 (1S)-1-isopropyl-3-oxocyclopentanecarboxylic acid 

Relevant articles and documents

Building the Housane: Diastereoselective Synthesis and Characterization of Bicyclo[2.1.0]pentane Carboxylic Acids

An approach to 1,3-disubstitued bicyclo[2.1.0]pentane (housane) derivatives was developed. The method relied on lithium bis(trimethylsilyl)amide-mediated intramolecular cyclization of trisubstitued cyclopentane carboxylates bearing a leaving group (at the C-4 position) and an additional substituent (at the C-3 atom), in turn synthesized from cyclopent-3-ene carboxylate. The synthetic sequence allowed for the preparation of both cis- and trans-1,3-disubstituted housane-1-carboxylic acids in diastereoselective manner on up to 80 g scale. In particular, bicyclic γ-amino acids - γ-aminobutyric acid analogues - were synthesized. It was shown that the bicyclo[2.1.0]pentane did not significantly affect pKa of the corresponding derivatives and slightly increased their hydrophilicity (by 0.07-0.25 Log P units) as compared to cyclopentane. X-ray diffraction studies showed that cis- and trans-1,3-disubstituted housanes can be considered as flattened analogues of the corresponding cyclopentane derivatives with fixed envelope conformation of the five-membered ring.

COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING NEURODEGENERATIVE DISORDERS

Compounds, pharmaceutical compositions, methods and kits are described for treating or preventing neurodegenerative diseases such as Alzheimer's disease.

Discovery of a potent and orally bioavailable CCR2 and CCR5 dual antagonist

This report describes the discovery of a potent, orally bioavailable CC chemokine receptor 2 (CCR2) antagonist which, while optimized for CCR2 potency, also had potent CC chemokine receptor 5 (CCR5) activity.