174800-02-3Relevant articles and documents
Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
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, (2016/05/09)
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
Capped dipeptide phenethylamide inhibitors of the HCV NS3 protease
Nizi, Emanuela,Koch, Uwe,Ontoria, Jesus M.,Marchetti, Antonella,Narjes, Frank,Malancona, Savina,Matassa, Victor G.,Gardelli, Cristina
, p. 2151 - 2154 (2007/10/03)
The N-terminal aminoacid of phenethylamide tripeptide inhibitors of the hepatitis C virus NS3 protease can be replaced with an α-hydroxy acid to obtain more 'drug like' inhibitors with low micromolar activity. The preferred S-configuration of the capping