1757-29-5

Basic information

• Product Name: 1H-pyrrole-2,5-dicarboxylic acid dimethyl ester
• Synonyms: 1H-pyrrole-2,5-dicarboxylic acid dimethyl ester
• CAS NO: 1757-29-5
• Molecular Weight: 183.164
• Mol File: 1757-29-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1H-pyrrole-2,5-dicarboxylic acid dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-pyrrole-2,5-dicarboxylic acid dimethyl ester(1757-29-5)
• EPA Substance Registry System: 1H-pyrrole-2,5-dicarboxylic acid dimethyl ester(1757-29-5)

Safety Data

• Hazardous Substances Data: 1757-29-5(Hazardous Substances Data)

Usage

Structure

1H-pyrrole-2,5-dicarboxylic acid with two methyl ester groups attached

Type

Ester of pyrrole-2,5-dicarboxylic acid

Usage

Building block in the synthesis of organic compounds and pharmaceuticals, potential use in the development of new materials with specific electronic and optical properties, potential as a ligand in metal coordination chemistry

Safety

Handle with care and in accordance with proper safety protocols.

Upstream product

• 186581-53-3 diazomethane 
• 18276-53-4 1-(trimethylsilyl)-1H-pyrrole 
• 124-38-9 carbon dioxide 
• 74-88-4 methyl iodide 

Downstream Products

• 266674-76-4 methyl 7,8-dimethoxy-3-(2-(3,4-dimethoxyphenyl)ethyl)-1-(3,4-dimethoxyphenyl)-[1]-benzopyrano[3,4-b]pyrrol-4(3H)-one-2-carboxylate 
• 266674-77-5 7,8-dimethoxy-3-(2-(3,4-dimethoxyphenyl)ethyl)-1-(3,4-dimethoxyphenyl)-[1]-benzopyrano[3,4-b]pyrrol-4(3H)-one-2-carboxylic acid 
• 1265221-68-8 C₄₂H₅₁NO₁₀ 
• 1265221-66-6 C₄₃H₅₃NO₁₀ 
• 1265221-64-4 C₃₁H₃₆BrNO₈ 
• 1265221-58-6 C₂₅H₂₄BrNO₈ 

Relevant articles and documents

Lithiations of 1-Trialkylsilylpyrroles: N to C Silyl Group Rearrangement

The sites of metallation with alkyl-lithium reagents of 1-trimethylsilyl- and 1-triethylsilyl-pyrroles have been explored under a variety of conditions.With short reaction times, BunLi reacts with 1-trimethylsilylpyrrole in hexane predominantly at the 2-position though with ButLi in pentane the unusual 3-metallated product is preferred.During prolonged reaction of 1-trimethylsilyl- and 1-triethylsilyl-pyrroles with ButLi, the 2-monolithio- and the 2,4- and 2,5-dilithio-intermediates are formed, in which, unexpectedly, the silyl groups migrate to the pyrrole 2-position.Under conditions favouring enhanced ionicity, BunLi cleaves the N-SiMe3 bond in preference to ring metallation.