18276-53-4

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
Trimethylsilylpyrazole is utilized as a key intermediate in the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for the creation of a wide range of bioactive compounds, contributing to the development of new drugs and pesticides.
Used as a Ligand in Organometallic Chemistry:
In organometallic chemistry, trimethylsilylpyrazole serves as a versatile ligand, capable of coordinating with transition metals to form stable complexes. This property is valuable for the study and application of organometallic compounds in various chemical reactions and catalytic processes.
Used in Materials Science:
Trimethylsilylpyrazole has been explored for its potential applications in materials science, particularly in the development of advanced polymers and functionalized surfaces. Its incorporation into these materials can enhance their properties, such as stability, reactivity, or selectivity, making it a promising candidate for the advancement of materials with specific functions or improved performance.
Overall, trimethylsilylpyrazole's diverse applications across different industries highlight its importance and potential for further research and development in the field of chemistry.

InChI:InChI=1/C13H28Cl2Si/c1-3-4-5-6-7-8-9-10-11-12-13-16(2,14)15/h3-13H2,1-2H3

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 109-97-7 pyrrole 
• 75-76-3 tetramethylsilane 
• 999-97-3 1,1,1,3,3,3-hexamethyl-disilazane 
• 81290-20-2 (trifluoromethyl)trimethylsilane 

Downstream Products

• 1080-37-1 Trifluorophenyl-1-pyrrolylphosphorane 
• 97-30-3 methyl D-glucopyranoside 
• 56784-04-4 methyl 2-trimethylsiloxytetracosanoate 
• 635-90-5 1-phenylpyrrole 
• 5145-71-1 1-(p-methoxyphenyl)pyrrole 
• 23351-08-8 1-(4-(methyl carboxylate) phenyl) pyrrole 
• 1258287-64-7 (CH₃)3SiNC₆H₅(C₆H₅)(C₆F₅)B(C₆F₅)2 
• 5158-60-1 methyl 6-deoxy-3-O-methyl-α-L-mannopyranoside 
• 4277-63-8 methyl 1H-pyrrole-1-carboxylate 
• 1193-62-0 methyl Pyrrole-2-carboxylate 
• 1757-29-5 1H-pyrrole-2,5-dicarboxylic acid dimethyl ester 
• 2703-17-5 methyl 1H-pyrrole-3-carboxylate 

Relevant academic research and scientific papers

Electrochemical Polymerization of N-Trimethylsilylpyrrole and Other Substituted Pyrroles Which Contain Si or Ge Atom(s) in Their Monomer Structures

N-Trimethylsilylpyrrole and three new compounds; N-trimethylgermylpyrrole, N-chloromethyldimethylsilylpyrrole, and N-pentamethyldisilanylpyrrole, were synthesized.These four monomers were electrochemically polymerized and four new organic conducting polym

NHC catalysed trimethylsilylation of terminal alkynes and indoles with Ruppert's reagent under solvent free conditions

An organo-catalytic protocol for the trimethylsilylation of terminal alkynes employing Ruppert's reagent (CF3SiMe3) as a trimethylsilyl source has been developed under solvent and fluoride free conditions. This method was found to be very effective as a variety of terminal alkynes bearing aliphatic or aromatic substituents underwent smooth transformation to their corresponding silylated products in excellent yields within a few minutes using N-heterocyclic carbene as an organo-catalyst. This methodology was also applied to the chemospecific N-silylation of indoles. This journal is

Palladium catalysed aryl amination reactions in supercritical carbon dioxide

Palladium catalysed C-N bond formation in supercritical carbon dioxide has been accomplished. Carbamic acid formation is avoided in part through the use of an N-silylamine as the coupling partner. Employing a catalyst system of Pd 2dba3 (1 mol%) and 2-dicyclohexylphosphino-2′, 4′,6′-triisopropyl-1,1′-biphenyl (X-Phos) (2 mol%) enabled the catalytic amination of aryl bromides and chlorides with N-silylanilines to be realised in excellent yield. Extension of the methodology to the N-arylation of N-silyldiarylamines, N-silylazoles and N-silylsulfonamides is reported. The Royal Society of Chemistry 2005.

Gas-phase heteroaromatic substitution. 9.1 Silylation of simple five-membered heteroaromatic rings by trimethylsilyl cations

Trimethylsilyl cation, obtained in the gas phase from the γ-radiolysis of CH4/(CH3)4Si mixtures, has been allowed to react with pyrrole, N-methylpyrrole, furan, and thiophene, both neat and in competition with toluene. Exp