17570-30-8Relevant articles and documents
Activated carbon as an efficient support for gold nanoparticles that catalyze the hydrogenation of nitro compounds with molecular hydrogen
Bondarenko, Grigory N.,Beletskaya, Irina P.
, p. 443 - 445 (2015)
A catalyst based on activated carbon with deposited gold nanoparticles and impregnated with ethylenediamine for selective hydrogenation of nitroarenes has been suggested.
Semi-synthesis, antibacterial activity, and molecular docking study of novel pleuromutilin derivatives bearing cinnamic acids moieties
Deng, Yu,Tang, Da,Wang, Qiu-ru,Huang, Sheng,Fu, Li-zhi,Li, Cheng-hong
, (2018/12/14)
To develop new antibiotics owning a special mechanism, we used the molecular assembly method to synthesize a series of novel pleuromutilin derivatives containing a cinnamic acid scaffold at the C-14 side chain. We evaluated their antibacterial activity an
4-AMINO CINNAMIC ACID PRODUCTION METHOD USING ENZYME
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Paragraph 0079-0080, (2017/01/02)
This 4-amino cinnamic acid production method using the enzyme ammonia lyase can efficiently convert 4-amino phenylalanine into 4-amino cinnamic acid. This 4-amino cinnamic acid production method is characterized by converting 4-amino phenylalanine into 4-amino cinnamic acid by using phenylalanine ammonia-lyase, which comprises the amino acid sequence represented in sequence number 2 derived from the Rhodotorula glutinis yeast.
TiCl4-mediated olefination of aldehydes with acetic acid and alkyl acetates: A stereoselective approach to (E)-α,β-unsaturated carboxylic acids and esters
Augustine, John Kallikat,Boodappa, Chandrakantha,Venkatachaliah, Srinivasa,Mariappan, Ayyampillai
, p. 3503 - 3506 (2014/06/10)
A new method has been developed for the preparation of α,β- unsaturated carboxylic acids and corresponding esters with (E)-stereoselectivity via the TiCl4-mediated olefination of aldehydes. The method, which uses readily available acetic acid or its alkyl esters as active methylene partners, is more flexible and complementary to conventional routes in the preparation of (E)-cinnamic acid derivatives.
Stereoselective synthesis of phenyl-1,2,3-triazoles containing (E)-vinyl halide group via a one-pot, three-component reaction
Zhang, Wensheng,Su, Changhui,Kuang, Chunxiang,Yang, Qing
experimental part, p. 1267 - 1275 (2011/05/11)
Phenyl-1,2,3-triazoles containing (E)-vinyl halide were readily synthesized via a one-pot, three-component reaction of 3-(4- or 2-azidophenyl)acrylic acid, NXS(X=Cl, Br and I) and 1-alkynes in MeCN-H2O (9:1v/v) catalyzed by LiOAc/CuI-sodium ascorbate syst
Cinnamoyl inhibitors of tissue transglutaminase
Pardin, Christophe,Pelletier, Joelle N.,Lubell, William D.,Keillor, Jeffrey W.
, p. 5766 - 5775 (2008/12/22)
(Figure Presented) Transglutaminases (TGases) catalyze the intermolecular cross-linking of certain proteins and tissue TGases (TG2) are involved in diverse biological processes. Unregulated, high TGase activities have been implicated in several physiological disorders, but few reversible inhibitors of TG2 have been reported. Herein, we report the synthesis of a series of novel trans-cinammoyl derivatives, discovered to be potent inhibitors of guinea pig liver transglutaminase. The most effective inhibitors evaluated can be sorted into two subclasses: substituted cinnamoyl benzotriazolyl amides and the 3-(substituted cinnamoyl)pyridines, referred to more commonly as azachalcones. Kinetic evaluation of both of these subclasses revealed that they display reversible inhibition and are competitive with acyl donor TGase substrates at IC50 values as low as 18 μM. An analysis of structure - activity relationships within these series of inhibitors permitted the identification of potentially important binding interactions. Further testing of some of the most potent inhibitors demonstrated their selectivity for TG2 and their potential for further development.
Hydrazinium monoformate: A new hydrogen donor. Selective reduction of nitrocompounds catalyzed by commercial zinc dust
Gowda, Shankare,Gowda, B. K. Kempe,Gowda, D. Channe
, p. 281 - 289 (2007/10/03)
The nitro group in aliphatic and aromatic nitro compounds also containing reducible substituents such as ethene, nitrile, acid, phenol, halogen, ester, etc., are selectively and rapidly reduced at room temperature to corresponding amines in good yields by employing hydrazinium monoformate, in the presence of commercial zinc dust. It was observed that, hydrazinium monoformate is more effective than hydrazine or formic acid and reduction of nitro group occurs without hydrogenolysis in the low cost zinc dust compared to expensive metals like palladium.
Carboline derivatives
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, (2008/06/13)
Carboline derivatives of formula (I) are potent and selective inhibitors of cyclic guanosine 3',5'-monophosphate specific phosphodiesterase (cGMP-specific PDE) and have utility in a variety of therapeutic areas where such inhibition is thought to be beneficial, including the treatment of cardiovascular disorders and erectile dysfunction.
A general method for the synthesis of O-alkyl N,O'-arylphosphoramidates and its application to the synthesis of a transition state analogue for carbamate hydrolysis
Taylor, Scott D.,Chen, Mei-Jin,Dinaut, A. Nicole,Batey, Robert A.
, p. 4223 - 4242 (2007/10/03)
O-alkyl N,O'-arylphosphoramidates were synthesized by reacting phenol and aniline derivatives with alkyldichlorophosphites to form phosphoramidites followed by oxidation with mCPBA. Selective cleavage of the alkyl group under mild, neutral conditions afforded the corresponding N,O-arylphosphoramidic acids. This methodology was used to synthesize a N,O-arylphosphoramidate transition state analogue for carbamate hydrolysis.
Benzene-azo-heterocyclic dyestuffs derived from alkyl aminocinnamates or aminocinnamide
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, (2008/06/13)
A dyestuff of the formula: STR1 IN WHICH --CH=CH--CO--Y is fixed in the 4 or 5 position, X is hydrogen or chlorine, Y is amino or alkoxy containing 1 to 4 carbon atoms, the p-phenylene nucleus A is unsubstituted or substituted by chlorine, alkyl containing 1 to 4 carbon atoms, alkoxy containing 1 to 4 carbon atoms, formylamino, acetylamino, propanoylamino, benzoylamino or cinnamoylamino, m is 0 or 1, and B represents the radical N-methyl (or ethyl)-4-hydroxy-2-oxo-quinolyl, 2-hydroxy-carbazolyl, 3-hydroxy-dibenzofuranyl, 2-phenylindolyl, N-methyl (or ethyl)-2-hydroxy-3-cyano-4-methyl-6-oxopyridyl, 3,6-dimethyl-4-hydroxy-1-phenyl-(4,5,-b)pyrazolopyridyl or the radical of formula: STR2 wherein R3 is hydrogen, methyl, alkoxycarbonyl, carbonamido or alkyl-substituted carbonamido and R4 is hydrogen, chlorine, nitro, methyl, cyano or, but only in the 3 or 4 position of the phenyl nucleus, sulphonamido, carbonamido, alkyl-substituted sulphonamido or alkyl-substituted carbonamido, the alkyl and alkoxy groups containing 1 to 4 carbon atoms. Such a dyestuff is used in the coloration of synthetic fibres.
