177908-37-1

Basic information

• Product Name: Cyclohexanol, 4-amino-1-methyl-, trans- (9CI)
• Synonyms: Cyclohexanol, 4-amino-1-methyl-, trans- (9CI);trans-4-AMino-1-Methylcyclohexanol;Cyclohexanol, 4-aMino-1-Methyl-, trans-;trans-4-AMino-1-Methylcyc...;(1r,4r)-4-aMino-1-Methylcyclohexan-1-ol
• CAS NO: 177908-37-1
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2001
• Product Categories: AMINEPRIMARY
• Mol File: 177908-37-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 203℃
• Flash Point: 77℃
• Appearance: /
• Density: 0.998
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 15.19±0.40(Predicted)
• CAS DataBase Reference: Cyclohexanol, 4-amino-1-methyl-, trans- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanol, 4-amino-1-methyl-, trans- (9CI)(177908-37-1)
• EPA Substance Registry System: Cyclohexanol, 4-amino-1-methyl-, trans- (9CI)(177908-37-1)

Safety Data

• Hazardous Substances Data: 177908-37-1(Hazardous Substances Data)

Usage

Uses

trans-4-Amino-1-methylcyclohexanol was used to design, synthesize and perform biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1.

Upstream product

• 17429-02-6 4-hydroxy-4-methylcyclohexanone 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 66336-42-3 8-methyl-1,4-dioxa-spiro[4.5]decan-8-ol 
• 1236405-14-3 benzyl ((1r,4r)-4-hydroxy-4-methylcyclohexyl)carbamate 
• 16801-63-1 benzyl N-(4-oxocyclohexyl)carbamate 
• 1236405-13-2 benzyl (trans-4-hydroxy-4-methylcyclohexyl)carbamate 

Relevant articles and documents

Application of Transaminases in a Disperse System for the Bioamination of Hydrophobic Substrates

The challenging bioamination of hydrophobic substrates has been attained through the employment of a disperse system consisting of a combination of a low polarity solvent (e. g. isooctane or methyl-tert-butylether), a non-ionic surfactant and a minimal amount of water. In these conditions, amine transaminases (ATA) were shown to efficiently carry out the reductive amination of variously substituted cyclohexanones, providing good conversions often coupled with a superior stereoselectivity if compared with the corresponding chemical reductive amination. An array of synthetically useful 4-substituted aminocyclohexanes was consequentially synthesized through biocatalysis, analyzed and stereochemically characterized. (Figure presented.).

1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS

A compound of formula (I), wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Lead Optimization toward Proof-of-Concept Tools for Huntington's Disease within a 4-(1 H -Pyrazol-4-yl)pyrimidine Class of Pan-JNK Inhibitors

Through medicinal chemistry lead optimization studies focused on calculated properties and guided by X-ray crystallography and computational modeling, potent pan-JNK inhibitors were identified that showed submicromolar activity in a cellular assay. Using in vitro ADME profiling data, 9t was identified as possessing favorable permeability and a low potential for efflux, but it was rapidly cleared in liver microsomal incubations. In a mouse pharmacokinetics study, compound 9t was brain-penetrant after oral dosing, but exposure was limited by high plasma clearance. Brain exposure at a level expected to support modulation of a pharmacodynamic marker in mouse was achieved when the compound was coadministered with the pan-cytochrome P450 inhibitor 1-aminobenzotriazole. (Chemical Presented)