17429-02-6

Basic information

• Product Name: 4-Methyl-4-hydroxycyclohexanone
• Synonyms: 4-Hydroxy-4-methylcyclohexanone;4-Methyl-4-hydroxycyclohexanone;4β-Hydroxy-4-methyl-1-cyclohexanone;4-hydroxy-4-methylcyclohexan-1-one;EOS-61241
• CAS NO: 17429-02-6
• Molecular Formula: C₇H₁₂O₂
• Molecular Weight: 128.17
• Mol File: 17429-02-6.mol
• Article Data: 32

Chemical Properties

• Melting Point: 199-200℃
• Boiling Point: 222.1°Cat760mmHg
• Flash Point: 89.3°C
• Appearance: /
• Density: 1.082g/cm³
• Vapor Pressure: 0.0212mmHg at 25°C
• Refractive Index: 1.486
• PKA: 14.69±0.20(Predicted)
• CAS DataBase Reference: 4-Methyl-4-hydroxycyclohexanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-4-hydroxycyclohexanone(17429-02-6)
• EPA Substance Registry System: 4-Methyl-4-hydroxycyclohexanone(17429-02-6)

Safety Data

• Hazardous Substances Data: 17429-02-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H12O2/c1-7(9)4-2-6(8)3-5-7/h9H,2-5H2,1H3

Upstream product

• 5718-73-0 1-isopropyl-4-methyl-2,3-dioxabicyclo[2,2,2]octane 
• 67-56-1 methanol 
• 23438-23-5 4-hydroxy-4-methyl-cyclohexa-2,5-dienone 
• 89794-52-5 1-methyl-1,4-cyclohexanediol 
• 124899-24-7 4-hydroxy-4-methylcyclohexanone-2,2-dimethyltrimethylene ketal 
• 66336-42-3 8-methyl-1,4-dioxa-spiro[4.5]decan-8-ol 
• 33082-73-4 6'-methylspiro<1,3-dioxolan-2,3'<7>oxabicyclo<4,1,0>heptane> 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 75-16-1 methylmagnesium bromide 
• 590-67-0 1-Methylcyclohexanol 
• 512-85-6 ascaridole 
• 131057-03-9 1-methyl-4-tetrahydropyranyloxy-1-cyclohexanol 
• 13482-22-9 4-hydroxycyclohexanone 
• 60739-53-9 4-(tetrahydro-2H-pyran-2-yloxy)cyclohexanone 

Downstream Products

• 56137-57-6 1,4-dimethyl-cyclohexane-1r,4t-diol 
• 124899-26-9 1-methylcyclohexane-trans-1,4-diol 
• 124899-25-8 (1s,4s)-1-methylcyclohexane-1,4-diol 
• 2885-39-4 (+/-)-E-73 
• 131057-05-1 4-[(R)-2-((1S,3S,5R)-5-Hydroxy-3,5-dimethyl-2-oxo-cyclohexyl)-2-triethylsilanyloxy-ethyl]-piperidine-2,6-dione 
• 131057-04-0 Acetic acid (1R,3S,5S)-3-[(R)-2-(2,6-dioxo-piperidin-4-yl)-1-triethylsilanyloxy-ethyl]-1,5-dimethyl-4-oxo-cyclohexyl ester 
• 131077-79-7 cis-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanone 
• 131077-79-7 trans-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanone 
• 523-86-4 (+/-)-4-<2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl>-2,6-piperidindione 
• 523-86-4 (+/-)-4-<2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl>-2,6-piperidindione 
• 523-86-4 (+/-)-4-<2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl>-2,6-piperidindione 
• 523-86-4 (+/-)-4-<2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl>-2,6-piperidindione 
• 131077-81-1 4-[2-((3R,5S)-3,5-Dimethyl-2-oxo-5-trimethylsilanyloxy-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione 
• 131077-81-1 4-[2-((3S,5S)-3,5-Dimethyl-2-oxo-5-trimethylsilanyloxy-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione 

Relevant articles and documents

1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS BCL-2 INHIBITORS FOR THE TREATMENT OF NEOPLASTIC AND AUTOIMMUNE DISEASES

The present invention relates to lH-pyrrolo[2,3-b]pyridine derivatives and related compounds as BCL-2 inhibitors for treating neoplastic, autoimmune or neurodegenerative diseases. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 162 to 233; examples 1 to 8; table; compound examples cpd-1 to cpd-135; biological examples 1 to 4).

Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy

Triple negative breast cancer (TNBC) is an aggressive disease with high relapse rates and few treatment options. Outlined in previous publications, we identified a series of potent, dual TTK/CLK2 inhibitors with strong efficacy in TNBC xenograft models. P

A vicarious, one-pot synthesis of benzo- and naphthofurans: Applications to the syntheses of stereumene B and paeoveitols

An interesting albeit unexpected deviation during attempted Tanabe γ-lactone annulation on 4-hydroxycyclohexanones has led to a general, one-pot synthesis of benzofurans and naphtho[2,3–b]furans from readily assembled precursors. The utility of this adaptable methodology has been demonstrated through concise syntheses of natural products, stereumene B, paeoveitol D and (±)-paeoveitol.