18221-50-6

Basic information

• Product Name: Phenol, 2,2'-(1,2-ethenediyl)bis-, (E)-
• CAS NO: 18221-50-6
• Molecular Formula: C14H12O2
• Molecular Weight: 212.248
• Mol File: 18221-50-6.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Phenol, 2,2'-(1,2-ethenediyl)bis-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phenol, 2,2'-(1,2-ethenediyl)bis-, (E)-(18221-50-6)
• EPA Substance Registry System: Phenol, 2,2'-(1,2-ethenediyl)bis-, (E)-(18221-50-6)

Safety Data

• Hazardous Substances Data: 18221-50-6(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 13460-50-9 metaboric acid 
• 69-72-7 salicylic acid 
• 84319-80-2 N,N'-dibutyl-c-3,c-4-bis(2-hydroxyphenyl)-r-1,c-2-cyclobutanedicarboxamide 
• 7734-65-8 t-3,c-4-bis(2-hydroxyphenyl)cyclobutane-r-1,t-2-dicarboxylic acid 
• 17601-37-5 (E)-2,2'-dimethoxystilbene 
• 89-95-2 2-methyl-benzyl alcohol 
• 959-36-4 salicyaldehyde azine 
• 5402-71-1 2,2',2''-[1,3,5]trithiane-2,4,6-triyl-tris-phenol 
• 7734-66-9 diethyl t-3,c-4-bis(2-hydroxyphenyl)cyclobutane-r-1,t-2-dicarboxylate 
• 86832-85-1 diethyl c-3,c-4-bis(2-hydroxyphenyl)cyclobutane-r-1,c-2-dicarboxylate 
• 84319-82-4 N-phenyl-c-3,c-4-bis(2-hydroxyphenyl)-r-1,c-2-cyclobutanedicarboximide 
• 84319-81-3 N-butyl-c-3,c-4-bis(2-hydroxyphenyl)-r-1,c-2-cyclobutanedicarboximide 
• 64820-07-1 ((2-methoxyphenyl)methyl)triphenylphosphonium bromide 

Downstream Products

• 1146729-49-8 (4bR,9bR)-cis-4b,9b-dihydrobenzofuro[3,2-b]benzofuran 
• 14227-13-5 trans-4b,9b-dihydrobenzofuro[3,2-b]benzofuran 
• 4986-28-1 2-(benzofuran-2-yl)phenol 
• 127003-27-4 2-(4-dimethylaminobutoxy)-2'-hydroxybibenzyl 
• 7156-35-6 (4br,9bc)-4b,9b-dihydrobenzobenzo<4,5>furo<2,3-d>furan 
• 650601-19-7 C₁₈H₂₂O₄ 
• 235766-62-8 1,2-bis(2-hydroxy-3-methylphenyl)ethane 
• 29338-20-3 1,2-bis-(2'-hydroxyphenyl)ethane 

Relevant articles and documents

Ionic-liquid-influenced expeditious and stereoselective synthesis of olefins

1-Butyl-3-methylimidazolium chloroaluminate, [bmim]Cl·.AlCl3 (molar fraction, N=0.67), ionic liquid has been used in combination with metallic Zn for the reductive coupling of carbonyl compounds to synthesize symmetrical olefins, with the Z-isomer formed predominantly. The ionic liquid played a dual role of Lewis acid catalyst and solvent. Copyright Taylor & Francis Group, LLC.

A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism

Targeting Streptococcus mutans is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product honokiol. Herein, a structure activity relationship (SAR) study to ascertain structural motifs key to inhibition is outlined. Furthermore, mechanism studies show that bacterial membrane disruption is central to the bacterial growth inhibition. During this process, it was discovered that analog C2 demonstrated a 4-fold better therapeutic index compared to the commercially available antimicrobial cetylpyridinium chloride (CPC) making it a viable alternative for oral care.

One-Step Synthesis of Substituted Benzofurans from ortho- Alkenylphenols via Palladium-Catalyzed C=H Functionalization

A dehydrogenative oxygenation of C(sp2)=H bonds with intramolecular phenolic hydroxy groups has been developed, which provides a straightforward and concise access to structurally diversely benzofurans from ortho-alkenylphenols. The reaction is catalyzed by palladium on carbon (Pd/C) without any oxidants and sacrificing hydrogen acceptors.