29338-20-3Relevant articles and documents
A Bisphenolic Honokiol Analog Outcompetes Oral Antimicrobial Agent Cetylpyridinium Chloride via a Membrane-Associated Mechanism
Ochoa, Cristian,Solinski, Amy E.,Nowlan, Marcus,Dekarske, Madeline M.,Wuest, William M.,Kozlowski, Marisa C.
, p. 74 - 79 (2019/11/20)
Targeting Streptococcus mutans is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product honokiol. Herein, a structure activity relationship (SAR) study to ascertain structural motifs key to inhibition is outlined. Furthermore, mechanism studies show that bacterial membrane disruption is central to the bacterial growth inhibition. During this process, it was discovered that analog C2 demonstrated a 4-fold better therapeutic index compared to the commercially available antimicrobial cetylpyridinium chloride (CPC) making it a viable alternative for oral care.
Ethylene-linked bis(phenol) ligands: Efficient synthesis, Ti(IV) coordination chemistry, and Lewis acid catalysis
Anthis, Jeffrey W.,Larsen, Andrew O.,White, Peter S.,Gagné, Michel R.
, p. 121 - 124 (2007/10/03)
We report herein an efficient synthesis of a series of chelating bis(aryloxide) ligands that can be diverged at a late stage to generate a variety of structures. Based on structural differences between linked and unlinked analogs of six-coordinate acid-ba
Low valent titanium in organic synthesis: Synthesis of diarylalkanes from o-hydroxyaromatic keto compounds
Nayak,Banerji
, p. 286 - 287 (2007/10/02)
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