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PHENYL 4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYLCARBAMATE is a carboxylic acid ester organic compound characterized by its complex molecular structure. It is known for its potential applications in the pharmaceutical industry due to its unique chemical properties.

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  • Carbamic acid,[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-, phenyl ester (9CI)/ LIDE PHARMA- Factory supply / Best price

    Cas No: 184177-81-9

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  • Posaconazole Intermediate CAS 184177-81-9 with factory price and top quality252742-72-6 Aprepitant Intermediate hot selling!!!!

    Cas No: 184177-81-9

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  • 184177-81-9 Structure
  • Basic information

    1. Product Name: PHENYL {4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL}CARBAMATE
    2. Synonyms: PHENYL {4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL}CARBAMATE;[4-[4-(4-Hydroxyphenyl)-1-piperazinyl]phenyl]carbamic acid phenyl ester;CarbaMic acid, [4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-, phenyl ester (9CI);Posaconazole Impurity 14;Phenyl (4-(4-(4-hydroxyphenyl);phenyl N-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]carbamate;4-(4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL)PHENYL CARBAMATE;Posaconazole Impurity 56
    3. CAS NO:184177-81-9
    4. Molecular Formula: C23H23N3O3
    5. Molecular Weight: 389.46
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 184177-81-9.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 603.9°C at 760 mmHg
    3. Flash Point: 319°C
    4. Appearance: /
    5. Density: 1.296
    6. Vapor Pressure: 3.52E-15mmHg at 25°C
    7. Refractive Index: 1.67
    8. Storage Temp.: Sealed in dry,Room Temperature
    9. Solubility: N/A
    10. PKA: 12.18±0.30(Predicted)
    11. CAS DataBase Reference: PHENYL {4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL}CARBAMATE(CAS DataBase Reference)
    12. NIST Chemistry Reference: PHENYL {4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL}CARBAMATE(184177-81-9)
    13. EPA Substance Registry System: PHENYL {4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYL}CARBAMATE(184177-81-9)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 184177-81-9(Hazardous Substances Data)

184177-81-9 Usage

Uses

Used in Pharmaceutical Industry:
PHENYL 4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYLCARBAMATE is used as a pharmaceutical intermediate for the synthesis of various drugs. Its complex structure allows it to serve as a key component in the development of new medications, potentially contributing to the treatment of various medical conditions.
Used in Antifungal Applications:
PHENYL 4-[4-(4-HYDROXYPHENYL)PIPERAZIN-1-YL]PHENYLCARBAMATE is identified as an impurity of Posaconazole (P689600), an orally active antifungal triazole. Posaconazole is effective against a wide range of fungal infections, and the presence of this carbamate compound may influence the drug's overall efficacy and safety profile. As an impurity, it is essential to monitor and control its levels in the final drug product to ensure optimal therapeutic outcomes and minimize potential side effects.

Check Digit Verification of cas no

The CAS Registry Mumber 184177-81-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,4,1,7 and 7 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 184177-81:
(8*1)+(7*8)+(6*4)+(5*1)+(4*7)+(3*7)+(2*8)+(1*1)=159
159 % 10 = 9
So 184177-81-9 is a valid CAS Registry Number.
InChI:InChI=1/C23H23N3O3/c27-21-12-10-20(11-13-21)26-16-14-25(15-17-26)19-8-6-18(7-9-19)24-23(28)29-22-4-2-1-3-5-22/h1-13,27H,14-17H2,(H,24,28)

184177-81-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name phenyl N-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]carbamate

1.2 Other means of identification

Product number -
Other names phenyl {4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl}carbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:184177-81-9 SDS

184177-81-9Relevant articles and documents

Preparation method of 4-[4-[4-(4-hydroxyphenyl) piperazine-1-yl] phenyl] phenyl carbamate

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, (2022/04/08)

The invention discloses a preparation method of 4-[4-[4-(4-hydroxyphenyl) piperazine-1-yl] phenyl] phenyl carbamate, which comprises the following steps: by taking 4-hydroxyaniline as a raw material, carrying out ring closing on the 4-hydroxyaniline and dichloroethylamine hydrochloride to synthesize 1-(4-hydroxyphenyl) piperazine with the purity of 95A% and the correction yield of 80%; 4-nitrochlorobenzene and the prepared 1-(4-hydroxyphenyl) piperazine are coupled to synthesize 4-(4-(4-nitrophenyl)-1-piperazinyl) phenol, the purity is 93 A%, and the correction yield is 88%; then carrying out nitro reduction to synthesize 1-(4-aminophenyl)-4-(4-hydroxyphenyl) piperazine with the purity of 98A% and the correction yield of 77%; and finally, synthesizing 4-[4-[4-(4-hydroxyphenyl) piperazine-1-yl] phenyl] phenyl carbamate with the purity of 98.7%, the content of 98.5 wt% and the correction yield of 83% by using phenyl chloroformate to protect phenolic hydroxyl groups. According to the invention, the high-purity target product 4-[4-[4-(4-hydroxyphenyl) piperazine-1-yl] phenyl] phenyl carbamate can be obtained through easily available raw materials and simple process steps.

Antifungal water-soluble compound as well as preparation method and application thereof (by machine translation)

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Paragraph 0095; 0107-0108, (2020/06/02)

The invention provides an antifungal water-soluble compound, a preparation method thereof and application, of the compound as I shown in formula. The compound has good antifungal effect and water solubility, can be used for treating and preventing,configuration optical isomers of the optical isomer SRSS obtained by chiral synthesis. (by machine translation)

Synthesis, Crystal Structure, Anti-Bone Cancer Activity and Molecular Docking Investigations of the Heterocyclic Compound 1-((2S,3S)-2-(Benzyloxy)Pentan-3-yl) -4-(4-(4-(4-Hydroxyphenyl)Piperazin-1-yl) Phenyl)-1H-1,2,4-Triazol-5(4H)-One

Lv,Zhang,Wang,Pan,Liu

, p. 1173 - 1179 (2019/08/12)

Heterocyclic compound 1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one (1) designed using 4-(4-(4-aminophenyl)piperazin-1-yl)phenol (2) and (S)-N′-(2-(benzyloxy)propylidene)formohydrazide (3) as start materials is successfully obtained via a multistep synthesis and finally characterized by IR, 1H NMR, and single crystal X-ray diffraction. In addition, the in vitro anticancer activities of newly synthesized compound 1 are evaluated against three human bone cancer cell lines U2OS, Saos-2, and GC9811. In addition, the molecular docking is used to study the potential antiviral activity of 1 by calculating the binding sites for the 1AS0 protein.

Preparation method of posaconazole

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Paragraph 0028; 0029; 0030; 0031, (2017/08/29)

The invention discloses a preparation method of posaconazole. The preparation method of the posaconazole provided by the invention comprises the following steps: in the presence of inorganic protonic acid, performing hydrolysis reaction on a compound II to obtain posaconazole I. The preparation method provided by the invention is easy and safe to operate, does not need any special equipment, is free from heavy metal residues, produces less reaction side products, and has high yield; a prepared product has high purity (chiral purity is larger than 99.90 percent, related substance purity is larger than 99.50 percent, all impurities are less than 0.1 percent, and raw materials meet the standard), is low in production cost, is environmentally friendly, and is suitable for industrial production. The formula of the posaconazole is shown in the description.

Process for the Preparation of Triazole Antifungal Drug, Its Intermediates and Polymorphs Thereof

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Paragraph 0325, (2014/12/09)

A process for the preparation of 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furanyl]methoxy]phenyl]-1-piperazinyl]phenyl]-2-[(1S,2S)-1-ethyl-2-hydroxypropyl]-2,4-dihydro-3H-1,2,4-triazol-3-one compound of formula-1, its intermediates and polymorphs thereof. (I)

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