18546-37-7

Basic information

• Product Name: 2-Deoxy-L-ribose
• Synonyms: 2-DEOXY-L-RIBOSE;L-ERYTHRO-PENTOFURANOSE;2-DEOXY-L-RIBOSE 99%;L-erythro-Pentose, 2-deoxy-;2-Deoxy-L-ribose,99%;2-Deoxy-L-ribose ,98%;(3R,4S)-3,4,5-Trihydroxypentanal;L-threo-2-deoxy-pentose
• CAS NO: 18546-37-7
• Molecular Formula: C₅H₁₀O₄
• Molecular Weight: 134.13
• EINECS: 2017-001-1
• Product Categories: Pharmaceutical Raw Materials;Carbohydrates
• Mol File: 18546-37-7.mol

Chemical Properties

• Melting Point: 69-72°C
• Boiling Point: 167.23°C (rough estimate)
• Flash Point: 154.6 °C
• Appearance: white to light beige crystalline powder
• Density: 1.0590 (rough estimate)
• Vapor Pressure: 2.53E-07mmHg at 25°C
• Refractive Index: 1.4050 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Methanol (Slightly), Water (Slightly)
• PKA: 13.58±0.20(Predicted)
• CAS DataBase Reference: 2-Deoxy-L-ribose(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Deoxy-L-ribose(18546-37-7)
• EPA Substance Registry System: 2-Deoxy-L-ribose(18546-37-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 24/25-37/39-36-26
• Hazardous Substances Data: 18546-37-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Deoxy-L-ribose is used as a pharmaceutical compound for its ability to induce apoptosis in cells. This property makes it a potential candidate for the development of treatments targeting various diseases, particularly those involving abnormal cell growth or cancer.
Used in Research Applications:
In the field of research, 2-Deoxy-L-ribose is utilized as a biochemical tool to study the effects of apoptosis and glutathione metabolism. Its unique properties allow scientists to gain insights into cellular processes and develop new therapeutic strategies.
Used in Drug Development:
2-Deoxy-L-ribose is used as a key component in the development of new drugs that target apoptosis and glutathione metabolism. Its potential application in cancer treatment and other therapeutic areas makes it a valuable compound for pharmaceutical research and development.
Used in Biochemical Analysis:
As a crystalline powder, 2-Deoxy-L-ribose is also used in biochemical analysis to study the structure and function of various biomolecules. Its isomer properties provide a basis for comparative studies and contribute to the understanding of molecular interactions in biological systems.

Purification Methods

Crystallise 2-deoxy--L-ribose from diethyl ether. It can also be purified by dissolving the ribose (7.3g) in EtOAc (3L) by reflux, decanting from any insoluble mate

InChI:InChI=1/C5H10O4/c6-2-1-4(8)5(9)3-7/h2,4-5,7-9H,1,3H2/t4-,5+/m1/s1

Upstream product

• 817621-87-7 2-deoxy-4,5-O-isopropylidene-L-ribose ethylene acetal 
• 79576-67-3 5,5-dimethoxy-pent-2c-en-1-ol 
• 79576-62-8 5-hydroxy-pent-3-ynal-dimethylacetal 

Downstream Products

• 106566-66-9 2-deoxy-L-ribonic acid 
• 123-76-2 levulinic acid 
• 101221-91-4 (2R,3R)-(-)-1-bromo-erythro-pentane-2,3-diol 
• 210702-79-7 β ethyl 2-deoxy-L-ribofuranoside 
• 210702-78-6 α ethyl 2-deoxy-L-ribofuranoside 
• 1318979-52-0 phenyl-4-O-benzoyl-2-deoxy-thio-α-L-ribopyranose 
• 1318979-54-2 phenyl-4-O-benzoyl-2-deoxy-thio-β-L-ribopyranose 
• 1318979-55-3 phenyl-3-O-benzoyl-2-deoxy-thio-α-L-ribopyranose 
• 1318979-47-3 phenyl-3,4-di-O-acetyl-2-deoxy-thio-L-ribopyranose 
• 1318979-51-9 phenyl-2-deoxy-thio-L-ribopyranose 
• 38996-14-4 (4R,5S)-4-hydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one 
• 3945-25-3 N-phenyl-α-DL-erythro-2-deoxy-pentopyranosylamine 
• 40156-63-6 2-Desoxy-DL-ribose-anil 
• 51255-17-5 (2S,3R)-2-Hydroxymethyl-5-methoxy-tetrahydro-furan-3-ol 

Relevant articles and documents

Production method of 2-deoxy-L-ribose compound

An aldehyde compound represented by the formula (1) is reacted with an organometallic compound represented by the formula (2) to give an alcohol compound represented by the formula (3), which is then subjected to deprotection of a hydroxyl group and production of aldehyde by acid hydrolysis. wherein R1 and R2 are each independently a hydroxyl-protecting group or R1 and R2 in combination show a hydroxyl-protecting group, R3 and R4 are each independently an alkyl group, an aralkyl group, an aryl group or a silyl group or R3 and R4 in combination show a cyclic alkyl group.